CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044749
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Coiled-coil domain-containing protein 14 
Protein Synonyms/Alias
  
Gene Name
 CCDC14 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
144TIPLVVQKETSSSDNubiquitination[1]
152ETSSSDNKKQIPNEAubiquitination[1]
153TSSSDNKKQIPNEASubiquitination[1]
298GVPCSLPKTDISAIPubiquitination[1]
324LPQQGIHKETDLLKCubiquitination[1, 2]
330HKETDLLKCIQTYLSubiquitination[1]
630TLQTSMAKLLSDLSVubiquitination[1, 3, 4, 5]
643SVDSARCKPGNNLTKubiquitination[1]
650KPGNNLTKSLLNIHDubiquitination[1]
658SLLNIHDKQLQHDPAubiquitination[1]
703EETIEPDKTYENVLSubiquitination[1, 2]
802SGLAVSGKENKLCTPubiquitination[1, 2]
805AVSGKENKLCTPVICubiquitination[1, 6]
817VICSSSTKEAEDAPEubiquitination[1, 3, 6]
825EAEDAPEKLSRASDMubiquitination[1, 2]
833LSRASDMKDTQLLKKubiquitination[1, 2]
840KDTQLLKKIKEAIGKubiquitination[1]
853GKIPAATKEPEEQTAubiquitination[1, 3, 6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 934 AA 
Protein Sequence
KKVREPTAVN SFYREASLPS VWASLRRREM VRSGARPGQV LSSGRHTGPA KLTNGKKATY 60
LRKIPRFNAD SGYSIHSDSE SQAETVHGLD GCASLLRDIL RNEDSGSETA YLENRSNSRP 120
LESKRYGSKK KRHEKHTIPL VVQKETSSSD NKKQIPNEAS ARSERDTSDL EQNWSLQDHY 180
RMYSPIIYQA LCEHVQTQMS LMNDLTSKNI PNGIPAVPCH APSHSESQAT PHSSYGLCTS 240
TPVWSLQRPP CPPKVHSEVQ TDGNSQFASQ GKTVSATCTD VLRNSFNTSP GVPCSLPKTD 300
ISAIPTLQQL GLVNGILPQQ GIHKETDLLK CIQTYLSLFR SHGKETHLDS QTHRSPTQSQ 360
PAFLATNEEK CAREQIREAT SERKDLNIHV RDTKTVKDVQ KAKNVNKTAE KVRIIKYLLG 420
ELKALVAEQE DSEIQRLITE MEACISVLPT VSGNTDIQVE IALAMQPLRS ENAQLRRQLR 480
ILNQQLREQQ KTQKPSGAVD CNLELFSLQS LNMSLQNQLE ESLKSQELLQ SKNEELLKVI 540
ENQKDENKKF SSIFKDKDQT ILENKQQYDI EITRIKIELE EALVNVKSSQ FKLETAEKEN 600
QILGITLRQR DAEVTRLREL TRTLQTSMAK LLSDLSVDSA RCKPGNNLTK SLLNIHDKQL 660
QHDPAPAHTS IMSYLNKLET NYSFTHSEPL STIKNEETIE PDKTYENVLS SRGPQNSNTR 720
GMEEASAPGI ISALSKQDSD EGSETMALIE DEHNLDNTIY IPFARSTPEK KSPLSKRLSP 780
QPQIRAATTQ LVSNSGLAVS GKENKLCTPV ICSSSTKEAE DAPEKLSRAS DMKDTQLLKK 840
IKEAIGKIPA ATKEPEEQTA CHGPSGCLSN SLQVKGNTVC DGSVFTSDLM SDWSISSFST 900
FTSRDEQDFR NGLAALDANI ARLQKSLRTG LLEK 934 
Gene Ontology
  
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS