UniProt Accession

 ARK74_HUMAN; Q8NHP1; Q5U614 

Genbank Protein ID

 AL035413; BC035351; AJ278012 

Genbank Nucleotide ID

 AAH35351.1; CAC79668.1 

Protein Name

 Aflatoxin B1 aldehyde reductase member 4 

Protein Synonyms/Alias

 AFB1 aldehyde reductase 3; AFB1-AR 3; Aldoketoreductase 7-like 

Gene Name

 AKR7L 

Gene Synonyms/Alias

 AFAR3; AKR7A4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
100	SQLETSLKRLQCPUV	ubiquitination	[1]
208	AGGLLTGKYKYEDKD	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity). 

Sequence Annotation

 NP_BIND 143 144 NADP (By similarity).
 NP_BIND 198 208 NADP (By similarity).
 NP_BIND 290 298 NADP (By similarity).
 ACT_SITE 49 49 Proton donor (By similarity).
 BINDING 44 44 NADP (By similarity).
 BINDING 113 113 Substrate (By similarity).
 BINDING 169 169 NADP (By similarity).
 BINDING 222 222 NADP (By similarity).
 BINDING 232 232 Substrate (By similarity).  

Keyword

 Alternative splicing; Complete proteome; NADP; Oxidoreductase; Polymorphism; Reference proteome; Selenocysteine. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 331 AA 

Protein Sequence

Gene Ontology

 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

  

PRINTS