UniProt Accession

 LDB1_MOUSE; P70662; O55204; Q1EQX2; Q71V68 

Genbank Protein ID

 U70375; U69270; U89488; AF030333; AF024524; AB250383; BC013624 

Genbank Nucleotide ID

 AAC52933.1; AAC52887.1; AAB96885.1; AAB94131.1; AAC40064.1; BAE95401.1; AAH13624.1 

Protein Name

 LIM domain-binding protein 1 

Protein Synonyms/Alias

 LDB-1; Carboxyl-terminal LIM domain-binding protein 2; CLIM-2; LIM domain-binding factor CLIM2; mLdb1; Nuclear LIM interactor 

Gene Name

 Ldb1 

Gene Synonyms/Alias

 Nli 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
277	LKTCLFQKWQRMVAP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. 

Sequence Annotation

 REGION 336 374 LIM-binding domain (LID).
 MOD_RES 2 2 N-acetylserine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Developmental protein; Nucleus; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 411 AA 

Protein Sequence

Gene Ontology

 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0001158; F:enhancer sequence-specific DNA binding; IDA:MGI.
 GO:0030274; F:LIM domain binding; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0003712; F:transcription cofactor activity; IEA:InterPro.
 GO:0000989; F:transcription factor binding transcription factor activity; IPI:MGI.
 GO:0009948; P:anterior/posterior axis specification; IMP:MGI.
 GO:0022607; P:cellular component assembly; IGI:MGI.
 GO:0021702; P:cerebellar Purkinje cell differentiation; IMP:MGI.
 GO:0010669; P:epithelial structure maintenance; IGI:MGI.
 GO:0001702; P:gastrulation with mouth forming second; IMP:MGI.
 GO:0001942; P:hair follicle development; IGI:MGI.
 GO:0060322; P:head development; IGI:UniProtKB.
 GO:0043973; P:histone H3-K4 acetylation; IMP:BHF-UCL.
 GO:0045647; P:negative regulation of erythrocyte differentiation; IMP:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0045785; P:positive regulation of cell adhesion; IGI:MGI.
 GO:0046985; P:positive regulation of hemoglobin biosynthetic process; IMP:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0060319; P:primitive erythrocyte differentiation; TAS:BHF-UCL.
 GO:0032784; P:regulation of DNA-dependent transcription, elongation; IMP:BHF-UCL.
 GO:0035019; P:somatic stem cell maintenance; IGI:MGI.
 GO:0006366; P:transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0000972; P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; IMP:BHF-UCL.
 GO:0016055; P:Wnt receptor signaling pathway; IMP:MGI. 

Interpro

 IPR002691; LIM-dom-bd. 

Pfam

  

SMART

  

PROSITE

  

PRINTS