CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030254
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PHD finger protein 3 
Protein Synonyms/Alias
 Protein Phf3 
Gene Name
 Phf3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
491PRKTVAAKHEVGHSKacetylation[1]
544QSCNSGVKSVKSQAHacetylation[1]
586HGHSGFSKEPPHPVQacetylation[2]
943KVATKIEKELFSFFRubiquitination[3]
1199INMPSVAKFVTKAYPubiquitination[3]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2025 AA 
Protein Sequence
MDIVDTFNHL IPTEHLDDAL FLGSNLENEV CEDFSTSQNV LEDSLKNMLS DKDPMLGSAS 60
NQFCLPVLDS NDPNFQMPCS TVVGLDDIMD EGVVKESGND TIDEEELILP NRSLRDRVED 120
NSVRSPRKSP RLMAQEQVRS LRQSTIAKRS NAATLSTKKP SGKTLSTSKV GVKPAERCQG 180
KEEVYASLKS EHPKESRRSG RHAEQMDVAP EVSASSVDSS VSSCAGMKEE AEFDPKHACN 240
NQGEVNVPSP ELDCPLLSET SASVEEKNIE ALMECKAKTN SSPLFKFPVR EDEQSDLVSG 300
ELNDTIEGKD AGGKPDQESE EVKFPCEGDQ TAEEPESSDV SSDSACANKN KAEKNEGAEC 360
HLELKNTVDI VDKPENSPQR NELETLGYGE DTESNDARLQ STEFNKSDLE EVDACAFEPE 420
ASTLENTICD VLDQNSKQLN ITQSIKMETA NLQDDRSGLE PKNIKPKHIK SVTHSKQSMT 480
TETPRKTVAA KHEVGHSKTK SNVKAVKRNS GEPEPQPDSQ RPVKVRKKQG DKVWKSQSCN 540
SGVKSVKSQA HSVLKRMPQD QNTMQISKPL THPHSDKLHG HSGFSKEPPH PVQTGHLVHS 600
SQKQSQKPQQ QAAVGKGSSH VKDEHDHPVS EHLKEDDKLK PRKPDRNLQP RQRRSSRSFS 660
LDEPPLFIPD NIATVKKEGS DQTTSIESKY MWTPSKQCGF CKKPHGNRFM VGCGRCDDWF 720
HGDCVGLSLS QAQQMGEEDK EYVCVRCCAE EDKKTDILDT EIFEAQAPIE AHSEDKRMEC 780
GKLTSSKHAV TDDKHRHSDD PGKHKVKILK RESGEGKTSS DSRDNEIKKW QLAPLRKLSQ 840
PHLPRRSSEE KSEKIAKEST ALASTGERVA RSGTHEKQET KKKKMEKGGP NVHPPAATSK 900
PSADQIRQSV RHSLKDILMK RLTDSNLKIP EEKAAKVATK IEKELFSFFR DTDAKYKNKY 960
RSLMFNLKDP KNNILFKKVL KGEVTPDHLI RMSPEELASK ELAAWRRREN RHTIEMIEKE 1020
QREVERRPIT KITHKGEIEI ESDAPMKEQE AAIEIQEPSA NKSMEKPDVS EKQKEEVDST 1080
SKDTTSQHRQ HLFDLNCKIC IGRMAPPIDD LSPKTVKVVV GGARKHSDNE AESLADALSS 1140
TTNILTSDLF EEEKQESPKS TFSPTPRPEM PGTVEVESTF LARLNFIWKG FINMPSVAKF 1200
VTKAYPVSGS PEYLTEDLPD SIQVGGRISP QTVWDYVEKI KASGTKEICV VRFTPVTEED 1260
QISYTLLFAY FSSRKRYGVA ANNMKQVKDM YLIPLGAADK IPHPLVPFDG PGLELHRPNL 1320
LLGLIIRQKL KRPHSASAGP SHTGETPESA PIVLPPDKKG KMESCTEEAA EEESDFFNSF 1380
TTVLHKQRNK PSQPLQEDLP TAAEPLMEVT KQEPPKPLRF LPGVLIGWDN QPSTLELANK 1440
PLPVDDILQS LLGTTGQVYE QAQPLVEQST LKEIPFINDQ ANPKVEKIDK VEVTEGDAKE 1500
IKVKAENISV STSKNSGEET SSVGSSSISP GPLASLSLRG KPPDVSTEAF LTNLSIPSKQ 1560
EESVENKERT LKRLLLQDQE NSLQDNRTSS DSPCWPGTGK GGMDGDGSGS GSGSGSGSEG 1620
PVANTRAPQF INLKRDPRQA AGRSQQTASE SKDAESCRNG DKHAASAPPH NKEPLAEAVG 1680
GEGKLPSQEK SSCVEQNDDS EAAPNSSSVE NLNSSQAEQA NPSQEDVLTQ NIETVHPFRR 1740
GSAPTSSRFE GGNTCQSEFP SKSVSFTCRS SSPRASTNFS PMRPQQPNLQ HLKSSPPGFP 1800
FPGPQNFPPQ NMFGFPPHLS PPLLPPPGFG FPQNPPMVPW PPVHVPGQPQ RMMGPLSQAS 1860
RYMGPQNFYQ VKDIRRPERR HSDPWGRQDQ QQPDRPFNRG KGDRQRFYSD SHHLKRERHD 1920
KDWEQESERH RHRDRSQERD RDRKSKEEAA AHKDKERPRL SHGDRAPDGK ASRDGKSADK 1980
KPDRPKGEDH EKEKERDKSK HKEGEKDRER YHKDRDHTDR VKSKR 2025 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR012921; SPOC_C.
 IPR003618; TFIIS_cen_dom.
 IPR017890; TFS2M.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00628; PHD
 PF07744; SPOC
 PF07500; TFIIS_M 
SMART
 SM00249; PHD
 SM00510; TFS2M 
PROSITE
 PS51321; TFIIS_CENTRAL
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS