| Tag | Content |
|---|
| CPLM ID | CPLM-020060 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Calsyntenin-3 |
Protein Synonyms/Alias | Alcadein-beta; Alc-beta |
Gene Name | CLSTN3 |
Gene Synonyms/Alias | CS3; KIAA0726 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 575 | RDFESLGKGMKVHVN | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May modulate calcium-mediated postsynaptic signals (By similarity). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (By similarity). |
Sequence Annotation | DOMAIN 29 145 Cadherin 1.
DOMAIN 146 246 Cadherin 2.
CARBOHYD 299 299 N-linked (GlcNAc...) (Potential).
CARBOHYD 327 327 N-linked (GlcNAc...) (Potential).
CARBOHYD 347 347 N-linked (GlcNAc...) (Potential).
CARBOHYD 507 507 N-linked (GlcNAc...) (Potential).
CARBOHYD 740 740 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Calcium; Cell adhesion; Cell membrane; Complete proteome; Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 956 AA |
Protein Sequence | MVLGCELSGS TRVVVGVEAL LTGASSPLPG VGPANKHKPW IEAEYQGIVM ENDNTVLLNP 60
PLFALDKDAP LRYAGEICGF RLHGSGVPFE AVILDKATGE GLIRAKEPVD CEAQKEHTFT 120
IQAYDCGEGP DGANTKKSHK ATVHVRVNDV NEFAPVFVER LYRAAVTEGK LYDRILRVEA 180
IDGDCSPQYS QICYYEILTP NTPFLIDNDG NIENTEKLQY SGERLYKFTV TAYDCGKKRA 240
ADDAEVEIQV KPTCKPSWQG WNKRIEYAPG AGSLALFPGI RLETCDEPLW NIQATIELQT 300
SHVAKGCDRD NYSERALRKL CGAATGEVDL LPMPGPNANW TAGLSVHYSQ DSSLIYWFNG 360
TQAVQVPLGG PSGLGSGPQD SLSDHFTLSF WMKHGVTPNK GKKEEETIVC NTVQNEDGFS 420
HYSLTVHGCR IAFLYWPLLE SARPVKFLWK LEQVCDDEWH HYALNLEFPT VTLYTDGISF 480
DPALIHDNGL IHPPRREPAL MIGACWTEEK NKEKEKGDNS TDTTQGDPLS IHHYFHGYLA 540
GFSVRSGRLE SREVIECLYA CREGLDYRDF ESLGKGMKVH VNPSQSLLTL EGDDVETFNH 600
ALQHVAYMNT LRFATPGVRP LRLTTAVKCF SEESCVSIPE VEGYVVVLQP DAPQILLSGT 660
AHFARPAVDF EGTNGVPLFP DLQITCSISH QVEAKKDESW QGTVTDTRMS DEIVHNLDGC 720
EISLVGDDLD PERESLLLDT TSLQQRGLEL TNTSAYLTIA GVESITVYEE ILRQARYRLR 780
HGAALYTRKF RLSCSEMNGR YSSNEFIVEV NVLHSMNRVA HPSHVLSSQQ FLHRGHQPPP 840
EMAGHSLASS HRNSMIPSAA TLIIVVCVGF LVLMVVLGLV RIHSLHRRVS GAGGPPGASS 900
DPKDPDLFWD DSALTIIVNP MESYQNRQSC VTGAVGGQQE DEDSSDSEVA DSPSSDERRI 960
IETPPHRY 968 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0045211; C:postsynaptic membrane; IEA:Compara. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0007156; P:homophilic cell adhesion; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |