UniProt Accession

 MIO_HUMAN; Q9NXC5; B2RTV6; O75216; Q7L551; Q9H092 

Genbank Protein ID

 AK000330; AC004982; CH471073; CH471073; BC005883; BC140833; BC140834; AL136892 

Genbank Nucleotide ID

 BAA91090.1; AAC31788.1; EAW93598.1; EAW93601.1; AAH05883.2; AAI40834.1; AAI40835.1; CAB66826.2 

Protein Name

 WD repeat-containing protein mio 

Protein Synonyms/Alias

  

Gene Name

 MIOS 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
99	LGQDHNSKFKDLIGK	ubiquitination	[1, 2]
393	LEKDIATKMRLRALS	ubiquitination	[3]
479	HNWSGLDKQSDIQNL	ubiquitination	[1, 2, 3, 4, 5]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

 REPEAT 58 100 WD 1.
 REPEAT 111 155 WD 2.
 REPEAT 182 221 WD 3.
 REPEAT 223 261 WD 4.
 REPEAT 265 306 WD 5.
 REPEAT 395 437 WD 6.
 MOD_RES 766 766 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 875 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat. 

Pfam

  

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS