UniProt Accession

 KCAB2_RAT; P62483; P97381; Q60942; Q64284 

Genbank Protein ID

 X76724 

Genbank Nucleotide ID

 CAA54142.1 

Protein Name

 Voltage-gated potassium channel subunit beta-2 

Protein Synonyms/Alias

 K(+) channel subunit beta-2; Kv-beta-2 

Gene Name

 Kcnab2 

Gene Synonyms/Alias

 Ckbeta2; Kcnb3 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
44	QFYRNLGKSGLRVSC	ubiquitination	[1]
104	VVLGNIIKKKGWRRS	ubiquitination	[1]
124	TKIFWGGKAETERGL	acetylation	[2]
124	TKIFWGGKAETERGL	ubiquitination	[1]
141	KHIIEGLKASLERLQ	ubiquitination	[1]
268	PYSRASLKGYQWLKD	acetylation	[2]
268	PYSRASLKGYQWLKD	ubiquitination	[1]
274	LKGYQWLKDKILSEE	acetylation	[2]
276	GYQWLKDKILSEEGR	acetylation	[2]
290	RRQQAKLKELQAIAE	acetylation	[2]
290	RRQQAKLKELQAIAE	ubiquitination	[1]
358	IDSILGNKPYSKKDY	acetylation	[2]
362	LGNKPYSKKDYRS**	acetylation	[2]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. 

Sequence Annotation

 NP_BIND 56 57 NADP.
 NP_BIND 188 189 NADP.
 NP_BIND 243 248 NADP.
 NP_BIND 323 329 NADP.
 BINDING 63 63 NADP.
 BINDING 85 85 NADP.
 BINDING 90 90 NADP.
 BINDING 214 214 NADP.
 BINDING 254 254 NADP.
 MOD_RES 9 9 Phosphoserine (By similarity).
 MOD_RES 20 20 Phosphoserine (By similarity).
 MOD_RES 25 25 Phosphotyrosine (By similarity).
 MOD_RES 124 124 N6-acetyllysine (By similarity).
 MOD_RES 360 360 Phosphotyrosine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Ion channel; Ion transport; NADP; Phosphoprotein; Potassium; Potassium transport; Reference proteome; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 367 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0044224; C:juxtaparanode region of axon; IEA:Compara.
 GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
 GO:0051291; P:protein heterooligomerization; IPI:RGD. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR005983; K_chnl_volt-dep_bsu_KCNAB.
 IPR005399; K_chnl_volt-dep_bsu_KCNAB-rel.
 IPR005401; K_chnl_volt-dep_bsu_KCNAB2.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

  

PRINTS

 PR01579; KCNAB2CHANEL.
 PR01577; KCNABCHANNEL.