| Tag | Content |
|---|
| CPLM ID | CPLM-012959 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Junctional sarcoplasmic reticulum protein 1 |
Protein Synonyms/Alias | Junctional-face membrane protein of 45 kDa homolog; JP-45 |
Gene Name | Jsrp1 |
Gene Synonyms/Alias | Jp45 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 96 | RIVPARRKPQAPPPL | ubiquitination | [1] | | 307 | RDLLEHGKLQAWAPR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage- sensitive calcium channel CACNA1S (By similarity). EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. |
Sequence Annotation | REGION 1 80 Mediates interaction with CACNA1S. |
Keyword | Alternative splicing; Complete proteome; Endoplasmic reticulum; Membrane; Reference proteome; Sarcoplasmic reticulum. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 332 AA |
Protein Sequence | MTTRGLEDLD GGLGSCLPSD DLPFLEEPAS GRRRESKARG TSRRADSSDW THVLQDPVAA 60
GAGDAGLKKM EKELAGKEST AGKAGTSPRI VPARRKPQAP PPLQPPPPPL QPPPRTPSDD 120
LPWGDLTLNK CLVLASLVAL LGSALQLCRD AVAGEVVAAP HPWVPPSSPP KKEASPAPKP 180
PVLVSPSGSP QPKPGPPQAR MQDEPELPGS PEATETRVER GGSISEASGE ESVPLGDRGS 240
QEKPRKEKPS KGEKLKKEKP RREKPRREDK SQVTGEPRQS LPRRWEAREG GRRPWGRDSR 300
DLLEHGKLQA WAPRRRHDRD DRPRQKRGKG RD 332 |
Gene Ontology | GO:0016529; C:sarcoplasmic reticulum; IDA:MGI. GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0072657; P:protein localization to membrane; IMP:MGI. GO:0060314; P:regulation of ryanodine-sensitive calcium-release channel activity; IMP:MGI. GO:0003009; P:skeletal muscle contraction; ISS:UniProtKB. |
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PRINTS | |