CPLM-023120

Genbank Nucleotide ID

Apoptotic chromatin condensation inducer in the nucleus

Protein Synonyms/Alias

Homo sapiens (Human)

Position	Peptide	Type	References
65	LPKSFKRKISVVSAT	ubiquitination	[1]
73	ISVVSATKGVPAGNS	ubiquitination	[1]
103	STATTQKKPSISITT	ubiquitination	[1]

[1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]

Functional Description

Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.

DOMAIN 72 106 SAP.
MOD_RES 166 166 Phosphoserine.
MOD_RES 169 169 Phosphoserine.
MOD_RES 208 208 Phosphoserine.
MOD_RES 210 210 Phosphoserine.
MOD_RES 216 216 Phosphoserine.
MOD_RES 240 240 Phosphoserine.
MOD_RES 243 243 Phosphoserine.
MOD_RES 254 254 Phosphothreonine.
MOD_RES 269 269 Phosphothreonine.
MOD_RES 295 295 Phosphoserine.
MOD_RES 326 326 Phosphothreonine.
MOD_RES 328 328 Phosphoserine.
MOD_RES 365 365 Phosphoserine.
MOD_RES 384 384 Phosphoserine.
MOD_RES 386 386 Phosphoserine.
MOD_RES 388 388 Phosphoserine.
MOD_RES 393 393 Phosphothreonine.
MOD_RES 400 400 Phosphoserine.
MOD_RES 410 410 Phosphoserine.
MOD_RES 414 414 Phosphothreonine.
MOD_RES 434 434 Phosphoserine.
MOD_RES 453 453 Phosphoserine.
MOD_RES 478 478 Phosphoserine.
MOD_RES 490 490 Phosphoserine.
MOD_RES 512 512 Phosphotyrosine.
MOD_RES 561 561 Phosphoserine.
MOD_RES 654 654 N6,N6,N6-trimethyllysine; by EHMT2;
MOD_RES 654 654 N6,N6-dimethyllysine; by EHMT2;
MOD_RES 655 655 Phosphoserine.
MOD_RES 657 657 Phosphoserine.
MOD_RES 682 682 Phosphothreonine.
MOD_RES 710 710 Phosphoserine.
MOD_RES 714 714 Phosphoserine.
MOD_RES 717 717 N6-acetyllysine.
MOD_RES 720 720 Phosphothreonine.
MOD_RES 729 729 Phosphoserine.
MOD_RES 825 825 Phosphoserine.
MOD_RES 838 838 Phosphoserine.
MOD_RES 840 840 Phosphothreonine (By similarity).
MOD_RES 895 895 Phosphoserine.
MOD_RES 898 898 Phosphoserine.
MOD_RES 987 987 Phosphoserine.
MOD_RES 990 990 Phosphoserine.
MOD_RES 1004 1004 Phosphoserine.
MOD_RES 1180 1180 Phosphoserine; by SRPK2 and PKB/AKT1.
MOD_RES 1329 1329 Phosphoserine (By similarity).
MOD_RES 1331 1331 Phosphoserine (By similarity).
MOD_RES 1332 1332 Phosphothreonine (By similarity).
CROSSLNK 5 5 Glycyl lysine isopeptide (Lys-Gly)

Acetylation; Alternative splicing; Apoptosis; Complete proteome; Direct protein sequencing; Isopeptide bond; Methylation; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005829; C:cytosol; TAS:Reactome.
GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0016887; F:ATPase activity; NAS:UniProtKB.
GO:0019899; F:enzyme binding; NAS:UniProtKB.
GO:0003676; F:nucleic acid binding; NAS:UniProtKB.
GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0030263; P:apoptotic chromosome condensation; IDA:UniProtKB.
GO:0030218; P:erythrocyte differentiation; IEP:UniProtKB.
GO:0045657; P:positive regulation of monocyte differentiation; IEP:UniProtKB.

IPR012677; Nucleotide-bd_a/b_plait.
IPR000504; RRM_dom.
IPR003034; SAP_dom.

SM00360; RRM
SM00513; SAP