| Tag | Content |
|---|
| CPLM ID | CPLM-015911 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Prickle-like protein 2 |
Protein Synonyms/Alias | |
Gene Name | PRICKLE2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 812 | TSDELLHKYSSYGLP | ubiquitination | [1] | | 820 | YSSYGLPKSSTLGGR | ubiquitination | [1] |
|
Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | |
Sequence Annotation | DOMAIN 18 126 PET.
DOMAIN 128 193 LIM zinc-binding 1.
DOMAIN 193 253 LIM zinc-binding 2.
DOMAIN 253 317 LIM zinc-binding 3.
MOD_RES 92 92 Phosphoserine (By similarity).
MOD_RES 543 543 Phosphoserine (By similarity).
MOD_RES 695 695 Phosphoserine (By similarity).
MOD_RES 731 731 Phosphoserine (By similarity).
MOD_RES 806 806 Phosphoserine (By similarity).
MOD_RES 841 841 Cysteine methyl ester (Probable).
LIPID 841 841 S-farnesyl cysteine. |
Keyword | Complete proteome; Disease mutation; Epilepsy; LIM domain; Lipoprotein; Membrane; Metal-binding; Methylation; Nucleus; Phosphoprotein; Prenylation; Reference proteome; Repeat; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 844 AA |
Protein Sequence | MVTVMPLEME KTISKLMFDF QRNSTSDDDS GCALEEYAWV PPGLKPEQVH QYYSCLPEEK 60
VPYVNSPGEK LRIKQLLHQL PPHDNEVRYC NSLDEEEKRE LKLFSSQRKR ENLGRGNVRP 120
FPVTMTGAIC EQCGGQINGG DIAVFASRAG HGVCWHPPCF VCTVCNELLV DLIYFYQDGK 180
IYCGRHHAEC LKPRCAACDE IIFADECTEA EGRHWHMKHF CCFECETVLG GQRYIMKEGR 240
PYCCHCFESL YAEYCDTCAQ HIGIDQGQMT YDGQHWHATE TCFCCAHCKK SLLGRPFLPK 300
QGQIFCSRAC SAGEDPNGSD SSDSAFQNAR AKESRRSAKI GKNKGKTEEP MLNQHSQLQV 360
SSNRLSADVD PLSLQMDMLS LSSQTPSLNR DPIWRSREEP YHYGNKMEQN QTQSPLQLLS 420
QCNIRTSYSP GGQGAGAQPE MWGKHFSNPK RSSSLAMTGH AGSFIKECRE DYYPGRLRSQ 480
ESYSDMSSQS FSETRGSIQV PKYEEEEEEE GGLSTQQCRT RHPISSLKYT EDMTPTEQTP 540
RGSMESLALS NATGLSADGG AKRQEHLSRF SMPDLSKDSG MNVSEKLSNM GTLNSSMQFR 600
SAESVRSLLS AQQYQEMEGN LHQLSNPIGY RDLQSHGRMH QSFDFDGGMA GSKLPGQEGV 660
RIQPMSERTR RRATSRDDNR RFRPHRSRRS RRSRSDNALH LASEREAISR LKDRPPLRAR 720
EDYDQFMRQR SFQESMGHGS RRDLYGQCPR TVSDLALQNA FGDRWGPYFA EYDWCSTCSS 780
SSESDNEGYF LGEPIPQPAR LRYVTSDELL HKYSSYGLPK SSTLGGRGQL HSRKRQKSKN 840
CIIS 844 |
Gene Ontology | GO:0016327; C:apicolateral plasma membrane; IEA:Compara. GO:0005737; C:cytoplasm; IDA:LIFEdb. GO:0016328; C:lateral plasma membrane; IEA:Compara. GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IEA:Compara. GO:0031175; P:neuron projection development; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |