UniProt Accession

 PFD2_YEAST; P40005; A2TBP1; D3DLP4 

Genbank Protein ID

 U18530; EF123144; AY558339; BK006939 

Genbank Nucleotide ID

 AAB64480.1; ABM97488.1; AAS56665.1; DAA07648.1 

Protein Name

 Prefoldin subunit 2 

Protein Synonyms/Alias

 Genes involved in microtubule biogenesis protein 4; Gim complex subunit 4; GimC subunit 4 

Gene Name

 GIM4 

Gene Synonyms/Alias

 PFD2; YEL003W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
11	RNNVFQAKYNEYKQI	acetylation	[1]
16	QAKYNEYKQILEELQ	acetylation	[1]
16	QAKYNEYKQILEELQ	ubiquitination	[2]
76	LPILETKKENIEGTI	ubiquitination	[2]
87	EGTISKMKETLIQTA	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. 

Sequence Annotation

  

Keyword

 Chaperone; Coiled coil; Complete proteome; Cytoplasm; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 111 AA 

Protein Sequence

Gene Ontology

 GO:0016272; C:prefoldin complex; IPI:SGD.
 GO:0015631; F:tubulin binding; IDA:SGD.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0007021; P:tubulin complex assembly; IMP:SGD. 

Interpro

 IPR027235; PFD2.
 IPR002777; PFD_beta-like.
 IPR009053; Prefoldin. 

Pfam

 PF01920; Prefoldin_2 

SMART

  

PROSITE

  

PRINTS