CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013506
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PAB-dependent poly(A)-specific ribonuclease subunit 3 
Protein Synonyms/Alias
 hPan3 
Gene Name
 PAN3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
540NADAYFTKRKWGQHEubiquitination[1]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, recruits polyadenylate-binding protein which in turn stimulates PAN2 nuclease activity. 
Sequence Annotation
 DOMAIN 492 754 Protein kinase.
 ZN_FING 43 71 C3H1-type.
 REGION 1 491 Interaction with polyadenylate-binding
 REGION 492 887 Interaction with PAN2.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Nonsense-mediated mRNA decay; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 887 AA 
Protein Sequence
MNSGGGLPPP SAAASPSSSS LAAAVAVVAP PGVGGVPGGA AVGVKLKYCR YYAKDKTCFY 60
GEECQFLHED PAAGAAPGLG LHSNSVPLAL AGAPVAGFPP GAVAGGGAGP PPGPKKPDLG 120
DPGTGAAAGG GGSSGGLDGP RLAIPGMDGG ALTDTSLTDS YFSTSFIGVN GFGSPVETKY 180
PLMQRMTNSS SSPSLLNDSA KPYSAHDPLT SPASSLFNDF GALNISQRRK TPNPTASEFI 240
PKGGSTSRLS NVSQSNMSAF SQVFSHPSMG SPATAGLAPG MSLSAGSSPL HSPKITPHTS 300
PAPRRRSHTP NPASYMVPSS ASTSVNNPVS QTPSSGQVIQ KETVGGTTYF YTDTTPAPLT 360
GMVFPNYHIY PPTAPHVAYM QPKANAPSFF MADELRQELI NRHLITMAQI DQADMPAVPT 420
EVDSYHSLFP LEPLPPPNRI QKSSNFGYIT SCYKAVNSKD DLPYCLRRIH GFRLVNTKCM 480
VLVDMWKKIQ HSNIVTLREV FTTKAFAEPS LVFAYDFHAG GETMMSRHFN DPNADAYFTK 540
RKWGQHEGPL PRQHAGLLPE SLIWAYIVQL SSALRTIHTA GLACRVMDPT KILITGKTRL 600
RVNCVGVFDV LTFDNSQNNN PLALMAQYQQ ADLISLGKVV LALACNSLAG IQRENLQKAM 660
ELVTINYSSD LKNLILYLLT DQNRMRSVND IMPMIGARFY TQLDAAQMRN DVIEEDLAKE 720
VQNGRLFRLL AKLGTINERP EFQKDPTWSE TGDRYLLKLF RDHLFHQVTE AGAPWIDLSH 780
IISCLNKLDA GVPEKISLIS RDEKSVLVVT YSDLKRCFEN TFQELIAAAN GQL 833 
Gene Ontology
 GO:0005813; C:centrosome; IDA:HPA.
 GO:0000932; C:cytoplasmic mRNA processing body; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0031251; C:PAN complex; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0004672; F:protein kinase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:Compara.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
 GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; TAS:Reactome.
 GO:0010606; P:positive regulation of cytoplasmic mRNA processing body assembly; IEA:Compara.
 GO:0006605; P:protein targeting; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR000571; Znf_CCCH. 
Pfam
  
SMART
 SM00356; ZnF_C3H1 
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS50103; ZF_C3H1 
PRINTS