| Tag | Content |
|---|
| CPLM ID | CPLM-009113 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Monocarboxylate transporter 4 |
Protein Synonyms/Alias | MCT 4; Solute carrier family 16 member 3 |
Gene Name | Slc16a3 |
Gene Synonyms/Alias | Mct4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 436 | ASEEKLHKPPVDVGV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). |
Sequence Annotation | MOD_RES 430 430 Phosphoserine.
MOD_RES 465 465 Phosphothreonine (By similarity).
MOD_RES 469 469 Phosphoserine (By similarity). |
Keyword | Cell membrane; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 470 AA |
Protein Sequence | MGGAVVDEGP TGIKAPDGGW GWAVLFGCFI ITGFSYAFPK AVSVFFKELM HEFGIGYSDT 60
AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL GMVAASFCRS IIQIYLTTGV 120
ITGLGLALNF QPSLIMLNRY FNKRRPIANG LAAAGSPVFL CALSPLGQLL QDHYGWRGGF 180
LILGGLLLNC CVCAALMRPL VAPQVGGGTE PRGPQRPPQR LLDLSVFRDR GFLIYAVAAS 240
IMVLGLFVPP VFVVSYAKDM GVPDTKAAFL LTILGFIDIF ARPTAGFITG LKKVRPYSVY 300
LFSFAMFFNG FTDLTGSTAT DYGGLVVFCI FFGISYGMVG ALQFEVLMAI VGTQKFSSAI 360
GLVLLLEAVA VLIGPPSGGK LLDATKVYKY VFILAGAEVL TSSLVLLLGN FFCIGKRKRP 420
EVTEPEEVAS EEKLHKPPVD VGVDSREVEH FLKAEPEKNG EVVHTPETSV 470 |
Gene Ontology | GO:0015629; C:actin cytoskeleton; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0031965; C:nuclear membrane; IEA:Compara. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0015355; F:secondary active monocarboxylate transmembrane transporter activity; IEA:InterPro. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |