CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042363
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Neurofibromin truncated 
Protein Synonyms/Alias
  
Gene Name
 NF1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
115MFGETLHKAVQGCGAubiquitination[1]
137PSLTFKEKVTSLKFKubiquitination[1]
144KVTSLKFKEKPTDLEubiquitination[1]
328GASLRKGKGNSSMDSubiquitination[2]
464ILNYPKAKMEDGQAAubiquitination[1]
540MGPVSERKGSMISVMubiquitination[1]
702LSFCQEMKFRNKMVEubiquitination[1]
1162LLWNNQEKIGQYLSSubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2502 AA 
Protein Sequence
NWEDNSVIFL LVQSMVVDLK NLLFNPSKPF SRGSQPADVD LMIDCLVSCF RISPHNNQHF 60
KICLAQNSPS TFHYVLVNSL HRIITNSALD WWPKIDAVYC HSVELRNMFG ETLHKAVQGC 120
GAHPAIRMAP SLTFKEKVTS LKFKEKPTDL ETRSYKYLLL SMVKLIHADP KLLLCNPRKQ 180
GPETQGSTAE LITGLVQLVP QSHMPEIAQE AMEALLVLHQ LDSIDLWNPD APVETFWEIS 240
SQMLFYICKK LTSHQMLSST EILKWLREIL ICRNKFLLKN KQADRSSCHF LLFYGVGCDI 300
PSSGNTSQMS MDHEELLRTP GASLRKGKGN SSMDSAAGCS GTPPICRQAQ TKLEVALYMF 360
LWNPDTEAVL VAMSCFRHLC EEADIRCGVD EVSVHNLLPN YNTFMEFASV SNMMSTGRAA 420
LQKRVMALLR RIEHPTAGNT EAWEDTHAKW EQATKLILNY PKAKMEDGQA AESLHKTIVK 480
RRMSHVSGGG SIDLSDTDSL QEWINMTGFL CALGGVCLQQ RSNSGLATYS PPMGPVSERK 540
GSMISVMSSE GNADTPVSKF MDRLLSLMVC NHEKVGLQIR TNVKDLVGLE LSPALYPMLF 600
NKLKNTISKF FDSQGQVLLT DTNTQFVEQT IAIMKNLLDN HTEGSSEHLG QASIETMMLN 660
LVRYVRVLGN MVHAIQIKTK LCQLVEVMMA RRDDLSFCQE MKFRNKMVEY LTDWVMGTSN 720
QAADDDVKCL TRDLDQASME AVVSLLAGLP LQPEEGDGVE LMEAKSQLFL KYFTLFMNLL 780
NDCSEVEDES AQTGGRKRGM SRRLASLRHC TVLAMSNLLN ANVDSGLMHS IGLGYHKDLQ 840
TRATFMEVLT KILQQGTEFD TLAETVLADR FERLVELVTM MGDQGELPIA MALANVVPCS 900
QWDELARVLV TLFDSRHLLY QLLWNMFSKE VELADSMQTL FRGNSLASKI MTFCFKVYGA 960
TYLQKLLDPL LRIVITSSDW QHVSFEVDPT RLEPSESLEE NQRNLLQMTE KFFHAIISSS 1020
SEFPPQLRSV CHCLYQVVSQ RFPQNSIGAV GSAMFLRFIN PAIVSPYEAG ILDKKPPPRI 1080
ERGLKLMSKI LQSIANHVLF TKEEHMRPFN DFVKSNFDAA RRFFLDIASD CPTSDAVNHS 1140
LSFISDGNVL ALHRLLWNNQ EKIGQYLSSN RDHKAVGRRP FDKMATLLAY LGPPEHKPVA 1200
DTHWSSLNLT SSKFEEFMTR HQVHEKEEFK ALKTLSIFYQ AGTSKAGNPI FYYVARRFKT 1260
GQINGDLLIY HVLLTLKPYY AKPYEIVVDL THTGPSNRFK TDFLSKWFVV FPGFAYDNVS 1320
AVYIYNCNSW VREYTKYHER LLTGLKGSKR LVFIDCPGKL AEHIEHEQQK LPAATLALEE 1380
DLKVFHNALK LAHKDTKVSI KVGSTAVQVT SAERTKVLGQ SVFLNDIYYA SEIEEICLVD 1440
ENQFTLTIAN QGTPLTFMHQ ECEAIVQSII HIRTRWELSQ PDSIPQHTKI RPKDVPGTLL 1500
NIALLNLGSS DPSLRSAAYN LLCALTCTFN LKIEGQLLET SGLCIPANNT LFIVSISKTL 1560
AANEPHLTLE FLEECISGFS KSSIELKHLC LEYMTPWLSN LVRFCKHNDD AKRQRVTAIL 1620
DKLITMTINE KQMYPSIQAK IWGSLGQITD LLDVVLDSFI KTSATGGLGS IKAEVMADTA 1680
VALASGNVKL VSSKVIGRMC KIIDKTCLSP TPTLEQHLMW DDIAILARYM LMLSFNNSLD 1740
VAAHLPYLFH VVTFLVATGP LSLRASTHGL VINIIHSLCT CSQLHFSEET KQVLRLSLTE 1800
FSLPKFYLLF GISKVKSAAV IAFRSSYRDR SFSPGSYERE TFALTSLETV TEALLEIMEA 1860
CMRDIPTCKW LDQWTELAQR FAFQYNPSLQ PRALVVFGCI SKRVSHGQIK QIIRILSKAL 1920
ESCLKGPDTY NSQVLIEATV IALTKLQPLL NKDSPLHKAL FWVAVAVLQL DEVNLYSAGT 1980
ALLEQNLHTL DSLRIFNDKS PEEVFMAIRN PLEWHCKQMD HFVGLNFNSN FNFALVGHLL 2040
KGYRHPSPAI VARTVRILHT LLTLVNKHRN CDKFEVNTQS VAYLAALLTV SEEVRSRCSL 2100
KHRKSLLLTD ISMENVPMDT YPIHHGDPSY RTLKETQPWS SPKGSEGYLA ATYPTVGQTS 2160
PRARKSMSLD MGQPSQANTK KLLGTRKSFD HLISDTKAPK RQEMESGITT PPKMRRVAET 2220
DYEMETQRIS SSQQHPHLRK VSVSESNVLL DEEVLTDPKI QALLLTVLAT LVKYTTDEFD 2280
QRILYEYLAE ASVVFPKVFP VVHNLLDSKI NTLLSLCQDP NLLNPIHGIV QSVVYHEESP 2340
PQYQTSYLQS FGFNGLWRFA GPFSKQTQIP DYAELIVKFL DALIDTYLPG IDEETSEESL 2400
LTPTSPYPPA LQSQLSITAN LNLSNSMTSL ATSQHSPASL PCSKSAVFMQ LFPHQGIDKE 2460
NVELSPTTGH CNSGRTRHGS ASQVQKQRSA GSFKRNSIKK IV 2502 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005096; F:GTPase activator activity; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR001251; CRAL-TRIO_dom.
 IPR001936; RasGAP.
 IPR023152; RasGAP_CS.
 IPR008936; Rho_GTPase_activation_prot. 
Pfam
 PF00616; RasGAP 
SMART
 SM00323; RasGAP
 SM00516; SEC14 
PROSITE
 PS50191; CRAL_TRIO
 PS00509; RAS_GTPASE_ACTIV_1
 PS50018; RAS_GTPASE_ACTIV_2 
PRINTS