UniProt Accession

 H0Y9G5_HUMAN; H0Y9G5 

Genbank Protein ID

 AC116317 

Genbank Nucleotide ID

  

Protein Name

 Wolframin 

Protein Synonyms/Alias

  

Gene Name

 WFS1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
130	DDFVEITKKYAKGVI	ubiquitination	[1]
134	EITKKYAKGVIPSSL	ubiquitination	[1, 2, 3]
155	DDDELAGKSPEDLPL	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 252 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
 GO:0055074; P:calcium ion homeostasis; IEA:InterPro. 

Interpro

 IPR026208; Wolframin.
 IPR026209; Wolframin_fam. 

Pfam

  

SMART

  

PROSITE

  

PRINTS

 PR02060; WOLFFAMILY.
 PR02061; WOLFRAMIN.