UniProt Accession

 RM41_MOUSE; Q9CQN7; Q8BJ44 

Genbank Protein ID

 AK003340; AK011837; AK032370; BC034728 

Genbank Nucleotide ID

 BAB22727.1; BAB27870.1; BAC27838.1; AAH34728.1 

Protein Name

 39S ribosomal protein L41, mitochondrial 

Protein Synonyms/Alias

 L41mt; MRP-L41 

Gene Name

 Mrpl41 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
103	PAIEKDFKEGTFDAN	acetylation	[1, 2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (By similarity). 

Sequence Annotation

  

Keyword

 Apoptosis; Cell cycle; Complete proteome; Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 135 AA 

Protein Sequence

Gene Ontology

 GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
 GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0006412; P:translation; ISS:UniProtKB. 

Interpro

 IPR019189; Ribosomal_L27/L41_mit. 

Pfam

 PF09809; MRP-L27 

SMART

  

PROSITE

  

PRINTS