| Tag | Content |
|---|
| CPLM ID | CPLM-014012 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein wntless homolog |
Protein Synonyms/Alias | Integral membrane protein GPR177; Protein evenness interrupted homolog; EVI; Putative NF-kappa-B-activating protein 373 |
Gene Name | WLS |
Gene Synonyms/Alias | C1orf139; GPR177; UNQ85/PRO18667 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 206 | LPVNEKKKINVGIGE | ubiquitination | [1] | | 215 | NVGIGEIKDIRLVGI | ubiquitination | [1] | | 408 | VFRNISGKQSSLPAM | ubiquitination | [1] | | 417 | SSLPAMSKVRRLHYE | ubiquitination | [1] | | 531 | QELFSASKYSFINDN | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity). |
Sequence Annotation | REGION 101 232 Interacts with Wnt proteins (By |
Keyword | Alternative splicing; Complete proteome; Cytoplasmic vesicle; Developmental protein; Golgi apparatus; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 541 AA |
Protein Sequence | MAGAIIENMS TKKLCIVGGI LLVFQIIAFL VGGLIGPTTA VSYMSVKCVD ARKNHHKTKW 60
FVPWGPNHCD KIRDIEEAIP REIEANDIVF SVHIPLPHME MSPWFQFMLF ILQLDIAFKL 120
NNQIRENAEV SMDVSLAYRD DAFAEWTEMA HERVPRKLKC TFTSPKTPEH EGRYYECDVL 180
PFMEIGSVAH KFYLLNIRLP VNEKKKINVG IGEIKDIRLV GIHQNGGFTK VWFAMKTFLT 240
PSIFIIMVWY WRRITMMSRP PVLLEKVIFA LGISMTFINI PVEWFSIGFD WTWMLLFGDI 300
RQGIFYAMLL SFWIIFCGEH MMDQHERNHI AGYWKQVGPI AVGSFCLFIF DMCERGVQLT 360
NPFYSIWTTD IGTELAMAFI IVAGICLCLY FLFLCFMVFQ VFRNISGKQS SLPAMSKVRR 420
LHYEGLIFRF KFLMLITLAC AAMTVIFFIV SQVTEGHWKW GGVTVQVNSA FFTGIYGMWN 480
LYVFALMFLY APSHKNYGED QSNGMQLPCK SREDCALFVS ELYQELFSAS KYSFINDNAA 540
SGI 543 |
Gene Ontology | GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0004871; F:signal transducer activity; ISS:UniProtKB. GO:0009948; P:anterior/posterior axis specification; IEA:Compara. GO:0001707; P:mesoderm formation; IEA:Compara. GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL. GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB. GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
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