CPLM-008007

Genbank Nucleotide ID

Exosome complex component MTR3

Protein Synonyms/Alias

mRNA transport regulator 3

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Position	Peptide	Type	References
30	TTTHVPEKKSTDLTP	acetylation	[1]

[1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]

Functional Description

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. MTR3 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation.

3D-structure; Complete proteome; Cytoplasm; Exosome; Nucleus; Reference proteome; RNA-binding; rRNA processing.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0000177; C:cytoplasmic exosome (RNase complex); IDA:SGD.
GO:0000176; C:nuclear exosome (RNase complex); IDA:SGD.
GO:0005730; C:nucleolus; IDA:SGD.
GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
GO:0070651; P:nonfunctional rRNA decay; IC:SGD.
GO:0071028; P:nuclear mRNA surveillance; IMP:SGD.
GO:0071039; P:nuclear polyadenylation-dependent CUT catabolic process; IMP:SGD.
GO:0071042; P:nuclear polyadenylation-dependent mRNA catabolic process; IC:SGD.
GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IMP:SGD.
GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IDA:SGD.
GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; IC:SGD.
GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; IC:SGD.
GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IMP:SGD.
GO:0034475; P:U4 snRNA 3'-end processing; IMP:SGD.

IPR001247; ExoRNase_PH_dom1.