CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026096
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear receptor co-repressor 1, isoform CRA_a 
Protein Synonyms/Alias
 Nuclear receptor corepressor 1 
Gene Name
 Ncor1 
Gene Synonyms/Alias
 mCG_23374 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
396SEQENNEKQMRQLSVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Receptor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2454 AA 
Protein Sequence
MSSSGYPPNQ GAFSTEQSRY PSHSVQYTFP STRHQQEFAV PDYRSSHIEV SQASQLLQQQ 60
QQQQQLRRRP SLLSEFHPGS DRPQERRTGY EQFHSGPSPV DHDSLESKRP RLEPVSDAHF 120
QRVSAAVLPL VHSLPEGLRS SADAKKDSAF GSKHEAPSSP LAGQPCGDDQ NASPSKLSKE 180
ELIQSMDRVD REIAKVEQQI LKLKKKQQQL EEEAAKPPEP EKPVSPPPVE QKHRSIVQII 240
YDENRKKAEE AHKIFEGLGP KVELPLYNQP SDTKVYHENI KTNQVMRKKL ILFFKRRNHA 300
RKQREQKICQ RYDQLMEAWE KKVDRIENNP RRKAKESKTR EYYEKQFPEI RKQREQQERF 360
QRVGQRGAGL SATIARSEHE ISEIIDGLSE QENNEKQMRQ LSVIPPMMFD AEQRRVKFIN 420
MNGLMEDPMK VYKDRQFMNV WTDHEKEIFK DKFIQHPKNF GLIASYLERK SVPDCVLYYY 480
LTKKNENYKA LVRRNYGKRR GRNQQIARPS QEEKVEEKEE DKAEKTEKKE EEKKDDEEKD 540
DKEDSKETTK EKDRTEATAE EPEEREQVTP RGRKTANSQG RRKGRVTRSM TSEAAAANAA 600
AAATEEPPPP LPPPPEPIST EPVETSRWTE EEMEVAKKGL VEHGRNWAAI AKMVGTKSEA 660
QCKNFYFNYK RRHNLDNLLQ QHKQKASRKP REERDVSQCE SVASTVSAQE DEDIEASNEE 720
ENPEDSEGAE NSSDTESAPS PSPVEAAKSS EDSSENAASR GNTEPVAELE ATTDPAPCAS 780
PSSAVPTTKP AERESVEAQV TDSASAETAE PMDVDHEECG AEGSSVLDPP APTKADSVDP 840
EMQVPENTAS KGEGDAKERD LESTSEKTEA RDEDVVVAEQ IERPEPQSDD DSSATCSADE 900
GVDGEPERQR VFPMDAKPSL LTPPGSILIS SPIKPNPLDL PQLQHRAAVI PPMVSCTPCN 960
IPIGTPVSGY ALYQRHIKAM HESALLEEQR QRQEQVDLEC RSSTSPCSTS KSPNREWEVL 1020
QPAPHQVITN LPEGVRLPTT RPTRPPPPLI PSSKTTVASE KPSFIMGGSI SQGTPGTYLS 1080
SHNQAYPQEA PKPSVGSISL GLPRQQESTK AAPLTYIKQE EFSPRSQNSQ PEGLLVRAQH 1140
EGVVRGTAGA VQEGSITRGT PASKISVETI SSLRGSITQG TPALPQAGIP TEALVKGPVS 1200
RMPIEESSPE KVREEAASKG HVIYEGKSGH ILSYDNIKNA REGTRSPRTA HEMSLKRSYE 1260
AVEGSIKQGM SMRESPVSAP LEGLICRALP RGSPHSDLKE RTVLSGSIMQ GTPRATAESF 1320
EDGLKYPKQI KRESPPIRAF EGAITKGKPY DGITTIKEMG RSIHEIPRQD ILTQESRKTP 1380
EVVQSTRPII EGSISQGTPI KFDNNSGQSA IKHNVKSLIT GPSKLPRGML EIVPENIKVV 1440
ERGKYEDVKA GEPVRARHTS VVSSGPSVLR STLHEAPKAQ LSPGLYDDSS ARRTPVSYQN 1500
TISRGSPMMN RTSDVSSSKS ASHERKSTLT PTQRESIPAK SPVPGVDPVV SHSPFDPHHR 1560
SSAAGEVYRS HLPTHLDPAM PFHRALDPAA AYLLQRQLSP TPGYPSQYQL YAMENTRQTI 1620
LNDYITSQQM QVNLRPDVTR GLSPREQPLG LPYPATRGII DLTNMPPTIL VPHAGGTSTP 1680
PMDRITYIPG TQVTFPPRPY NAASLSPGHP THLAAAASAE REREREREKE RERERERERE 1740
RERERIAAAP ADLYLRPGSE QPGRPGSHGY VRSPSPSVRT QETILQQRPS VFQGTNGTSV 1800
ITPLDPTAQL RIMPLPSGGP SISQGLPASR YNTAADALAA LVDAAASAPQ MDVSKTKESK 1860
HEAARLEENL RSRSAAVSEQ QQLEQKNLEV EKRSVQCVCT SSALPSGKAQ PHASVVYSEA 1920
GKDKGPPPKS RYEEELRTRG KTTITAANFI DVIITRQIAS DKDARERGSQ SSDSSSSLSS 1980
HRYETASDAI EVISPASSPA PPQEKPQAYQ PDMVKANQAE NESTRQYEGP LHHYRSQQES 2040
PSPQQQPPLP PSSQSEGMGQ VPRTHRLITL ADHICQIITQ DFARNQVPSQ PSTSTFQTSP 2100
SALSSTPVRT KTSSRYSPES QSQTVLHPRP GPRVSPENLV DKSRGSRPGK SPERSHIPSE 2160
PYEPISPPQG PAVHEKQDSM LLLSQRGVDP AEQRSDSRSP GSISYLPSFF TKLESTSPMV 2220
KSKKQEIFRK LNSSGGGDSD MAAAQPGTEI FNLPAVTTSG AVSSRSHSFA DPASNLGLED 2280
IIRKALMGSF DDKVEDHGVV MSHPVGIMPG SASTSVVTSS EARRDEGEPS PHAGVCKPKL 2340
INKSNSRKSK SPIPGQSYLG TERPSSVSSV HSEGDYHRQT PGWAWEDRPS STGSTQFPYN 2400
PLTIRMLSST PPTQIACAPS AITQAAPHQQ NRIWEREPAP LLSAQYETLS DSDD 2454 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0016580; C:Sin3 complex; IEA:Compara.
 GO:0005876; C:spindle microtubule; IEA:Compara.
 GO:0005667; C:transcription factor complex; IPI:MGI.
 GO:0017053; C:transcriptional repressor complex; IPI:MGI.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0035033; F:histone deacetylase regulator activity; IDA:MGI.
 GO:0046965; F:retinoid X receptor binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0046966; F:thyroid hormone receptor binding; IDA:MGI.
 GO:0003714; F:transcription corepressor activity; IGI:MGI.
 GO:0002361; P:CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; IMP:MGI.
 GO:0042632; P:cholesterol homeostasis; IMP:MGI.
 GO:0032922; P:circadian regulation of gene expression; IGI:MGI.
 GO:0060318; P:definitive erythrocyte differentiation; IMP:MGI.
 GO:0046329; P:negative regulation of JNK cascade; IEA:Compara.
 GO:0014067; P:negative regulation of phosphatidylinositol 3-kinase cascade; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0031065; P:positive regulation of histone deacetylation; IDA:MGI.
 GO:0072362; P:regulation of glycolysis by negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0072368; P:regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0040014; P:regulation of multicellular organism growth; IGI:MGI.
 GO:0051225; P:spindle assembly; IEA:Compara.
 GO:0021794; P:thalamus development; IMP:MGI. 
Interpro
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom. 
Pfam
 PF00249; Myb_DNA-binding 
SMART
 SM00717; SANT 
PROSITE
 PS51293; SANT 
PRINTS