UniProt Accession

 OPTN_HUMAN; Q96CV9; B3KP00; D3DRS4; D3DRS8; Q5T672; Q5T673; Q5T674; Q5T675; Q7LDL9; Q8N562; Q9UET9; Q9UEV4; Q9Y218 

Genbank Protein ID

 AF061034; AF061034; AF420371; AF420372; AF420373; AF283527; AF283520; AF283521; AF283522; AF283523; AF283524; AF283525; AF283526; AK055403; AL355355; AL355355; AL355355; AL355355; CH471072; CH471072; CH471072; CH471072; CH471072; CH471072; CH471072; BC013876; BC032762; AF049614 

Genbank Nucleotide ID

 AAC16046.1; AAC16047.1; AAL76327.1; AAL76328.1; AAL76329.1; AAG00497.1; AAG00497.1; AAG00497.1; AAG00497.1; AAG00497.1; AAG00497.1; AAG00497.1; AAG00497.1; BAG51512.1; CAI16549.1; CAI16550.1; CAI16551.1; CAI16552.1; EAW86301.1; EAW86302.1; EAW86303.1; EAW86304.1; EAW86306.1; EAW86308.1; EAW86309.1; AAH13876.1; AAH32762.1; AAC26850.1 

Protein Name

 Optineurin 

Protein Synonyms/Alias

 E3-14.7K-interacting protein; FIP-2; Huntingtin yeast partner L; Huntingtin-interacting protein 7; HIP-7; Huntingtin-interacting protein L; NEMO-related protein; Optic neuropathy-inducing protein; Transcription factor IIIA-interacting protein; TFIIIA-IntP 

Gene Name

 OPTN 

Gene Synonyms/Alias

 FIP2; GLC1E; HIP7; HYPL; NRP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
313	ELQEAHTKLSKAELM	ubiquitination	[1]
316	EAHTKLSKAELMKKR	ubiquitination	[1]
321	LSKAELMKKRLQEKC	ubiquitination	[1]
442	QLQMDEMKQTIAKQE	ubiquitination	[1]
495	LQLAVLLKENDAFED	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death. 

Sequence Annotation

 REGION 58 209 Interaction with Rab8.
 REGION 411 577 Interaction with HD.
 REGION 412 520 Interaction with MYO6.
 MOTIF 474 479 UBAN.
 MOD_RES 177 177 Phosphoserine; by TBK1.
 MOD_RES 342 342 Phosphoserine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Amyotrophic lateral sclerosis; Coiled coil; Complete proteome; Cytoplasm; Disease mutation; Glaucoma; Golgi apparatus; Neurodegeneration; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 577 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
 GO:0008219; P:cell death; TAS:ProtInc.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0090161; P:Golgi ribbon formation; IDA:UniProtKB.
 GO:0043001; P:Golgi to plasma membrane protein transport; IMP:UniProtKB.
 GO:0000042; P:protein targeting to Golgi; IMP:UniProtKB.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR021063; NEMO_N. 

Pfam

 PF11577; NEMO 

SMART

  

PROSITE

  

PRINTS