CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037159
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein polybromo-1 
Protein Synonyms/Alias
  
Gene Name
 PBRM1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
414PFYHLPSKKKYPDYYacetylation[1, 2]
569ILEPMDLKIIEHNIRubiquitination[3]
579EHNIRNDKYAGEEGMubiquitination[3]
670NEVYEAVKNYTDKRGubiquitination[3]
701PDYYLTIKKPMDMEKubiquitination[4]
754KDALVLHKVLLETRRubiquitination[4]
1018FLEKEVFKSDYYNKVubiquitination[2, 3]
1024FKSDYYNKVPVSKILubiquitination[2, 3]
1073TKSFKKIKLWTMPISubiquitination[2, 3]
1180PRVGRIEKVWVRDGAubiquitination[3]
1292DEIYYFRKPIVPQKEubiquitination[2]
1397SEMRAVIKAQHPDYSubiquitination[2, 3, 4, 5, 6]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Bromodomain; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1461 AA 
Protein Sequence
MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY 60
KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK LKMEEYDDVN LLTADFQLLF 120
NNAKSYYKPD SPEYKAACKL WDLYLRTRNE FVQKGEADDE DDDEDGQDNQ GTVTEGSSPA 180
YLKEILEQLL EAIVVATNPS GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG 240
SYKSIHAMAK DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMR 300
TPSNLAAARL TGPSHSKGSL GEERNPTSKY YRNKRAVQGG RLSAITMALQ YGSESEEDAA 360
LAAARYEEGE SEAESITSFM DVSNPFYQLY DTVRSCRNNQ GQLIAEPFYH LPSKKKYPDY 420
YQQIKMPISL QQIRTKLKNQ EYETLDHLEC DLNLMFENAK RYNVPNSAIY KRVLKLQQVM 480
QAKKKELARR DDIEDGDSMI SSATSDTGSA KRKSKKNIRK QRMKILFNVV LEAREPGSGR 540
RLCDLFMVKP SKKDYPDYYK IILEPMDLKI IEHNIRNDKY AGEEGMIEDM KLMFRNARHY 600
NEEGSQVYND AHILEKLLKE KRKELGPLPD DDDMASPKLK LSRKSGISPK KSKYMTPMQQ 660
KLNEVYEAVK NYTDKRGRRL SAIFLRLPSR SELPDYYLTI KKPMDMEKIR SHMMANKYQD 720
IDSMVEDFVM MFNNACTYNE PESLIYKDAL VLHKVLLETR RDLEGDEDSH VPNVTLLIQE 780
LIHNLFVSVM SHQDDEGRCY SDSLAEIPAV DPNFPNKPPL TFDIIRKNVE NNRYRRLDLF 840
QEHMFEVLER ARRMNRTDSE IYEDAVELQQ FFIKIRDELC KNGEILLSPA LSYTTKHLHN 900
DVEKERKEKL PKEIEEDKLK REEEKRAEKS EDSSGAAGLS GLHRTYSQDC SFKNSMYHVG 960
DYVYVEPAEA NLQPHIVCIE RLWEDSAGEK WLYGCWFYRP NETFHLATRK FLEKEVFKSD 1020
YYNKVPVSKI LGKCVVMFVK EYFKLCPENF RDEDVFVCES RYSAKTKSFK KIKLWTMPIS 1080
SVRFVPRDVP LPVVRVASVF ANADKGDDEK NTDNSEDSRA EDNFNLEKEK EDVPVEMSNG 1140
EPGCHYFEQL HYNDMWLKVG DCVFIKSHGL VRPRVGRIEK VWVRDGAAYF YGPIFIHPEE 1200
TEHEPTKMFY KKEVFLSNLE ETCPMTCILG KCAVLSFKDF LSCRPTEIPE NDILLCESRY 1260
NESDKQMKKF KGLKRFSLSA KVVDDEIYYF RKPIVPQKEP SPLLEKKIQL LEAKFAELEG 1320
GDDDIEEMGE EDSEVIEPPS LPQLQTPLAS ELDLMPYTPP QSTPKSAKGS AKKEGSKRKI 1380
NMSGYILFSS EMRAVIKAQH PDYSFGELSR LVGTEWRNLE TAKKAEYEGM MGGYPPGLPP 1440
LQGPVDGLVS MGSMQPLHPG G 1461 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro. 
Interpro
 IPR001025; BAH_dom.
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR009071; HMG_box_dom. 
Pfam
 PF01426; BAH
 PF00439; Bromodomain
 PF00505; HMG_box 
SMART
 SM00439; BAH
 SM00297; BROMO
 SM00398; HMG 
PROSITE
 PS51038; BAH
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS50118; HMG_BOX_2 
PRINTS
 PR00503; BROMODOMAIN.