UniProt Accession

 F7C312_MOUSE; F7C312 

Genbank Protein ID

 AC152453 

Genbank Nucleotide ID

  

Protein Name

 Endoplasmin 

Protein Synonyms/Alias

  

Gene Name

 Hsp90b1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
15	LEEDEAAKEEKEESD	acetylation	[1]
18	DEAAKEEKEESDDEA	acetylation	[1]
80	LFDEYGSKKSDYIKL	acetylation	[2]
80	LFDEYGSKKSDYIKL	succinylation	[2]
80	LFDEYGSKKSDYIKL	ubiquitination	[3]
86	SKKSDYIKLYVRRVF	acetylation	[4]
104	DFHDMMPKYLNFVKG	acetylation	[4]
110	PKYLNFVKGVVDSDD	acetylation	[4]
110	PKYLNFVKGVVDSDD	ubiquitination	[3]
131	RETLQQHKLLKVIRK	acetylation	[1, 4]
131	RETLQQHKLLKVIRK	ubiquitination	[3]
143	IRKKLVRKTLDMIKK	acetylation	[4]
149	RKTLDMIKKIADEKY	acetylation	[1]
155	IKKIADEKYNDTFWK	acetylation	[2, 4]
155	IKKIADEKYNDTFWK	succinylation	[2]
162	KYNDTFWKEFGTNIK	acetylation	[4]
213	RMKEKQDKIYFMAGS	acetylation	[2, 4]
213	RMKEKQDKIYFMAGS	succinylation	[2]
223	FMAGSSRKEAESSPF	acetylation	[2]
223	FMAGSSRKEAESSPF	succinylation	[2]
269	KRFQNVAKEGVKFDE	acetylation	[2]
269	KRFQNVAKEGVKFDE	succinylation	[2]
273	NVAKEGVKFDESEKT	acetylation	[1, 5]
289	ESREATEKEFEPLLN	acetylation	[4]
299	EPLLNWMKDKALKDK	acetylation	[4]
309	ALKDKIEKAVVSQRL	acetylation	[2, 4]
309	ALKDKIEKAVVSQRL	succinylation	[2]
339	GNMERIMKAQAYQTG	ubiquitination	[3]
347	AQAYQTGKDISTNYY	acetylation	[1, 4]
347	AQAYQTGKDISTNYY	ubiquitination	[3]
358	TNYYASQKKTFEINP	acetylation	[1, 2]
358	TNYYASQKKTFEINP	succinylation	[2]
358	TNYYASQKKTFEINP	ubiquitination	[3]
359	NYYASQKKTFEINPR	acetylation	[4]

Reference

 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 373 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0050750; F:low-density lipoprotein particle receptor binding; ISO:MGI.
 GO:0019903; F:protein phosphatase binding; ISO:MGI.
 GO:0031247; P:actin rod assembly; ISO:MGI.
 GO:0071318; P:cellular response to ATP; ISO:MGI.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0043666; P:regulation of phosphoprotein phosphatase activity; ISO:MGI.
 GO:0006950; P:response to stress; IEA:InterPro. 

Interpro

 IPR001404; Hsp90.
 IPR020568; Ribosomal_S5_D2-typ_fold. 

Pfam

 PF00183; HSP90 

SMART

  

PROSITE

  

PRINTS