CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007938
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rap1 GTPase-activating protein 1 
Protein Synonyms/Alias
 Rap1GAP; Rap1GAP1 
Gene Name
 RAP1GAP 
Gene Synonyms/Alias
 KIAA0474; RAP1GA1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
262VYCNFRNKEIMFHVSacetylation[1]
378NAEYACYKAEKFAKLacetylation[1]
384YKAEKFAKLEERTRAacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. 
Sequence Annotation
 DOMAIN 1 17 GoLoco.
 DOMAIN 181 397 Rap-GAP.
 MOD_RES 484 484 Phosphoserine.
 MOD_RES 499 499 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Golgi apparatus; GTPase activation; Membrane; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 663 AA 
Protein Sequence
MIEKMQGSRM DEQRCSFPPP LKTEEDYIPY PSVHEVLGRE GPFPLILLPQ FGGYWIEGTN 60
HEITSIPETE PLQSPTTKVK LECNPTARIY RKHFLGKEHF NYYSLDAALG HLVFSLKYDV 120
IGDQEHLRLL LRTKCRTYHD VIPISCLTEF PNVVQMAKLV CEDVNVDRFY PVLYPKASRL 180
IVTFDEHVIS NNFKFGVIYQ KLGQTSEEEL FSTNEESPAF VEFLEFLGQK VKLQDFKGFR 240
GGLDVTHGQT GTESVYCNFR NKEIMFHVST KLPYTEGDAQ QLQRKRHIGN DIVAVVFQDE 300
NTPFVPDMIA SNFLHAYVVV QAEGGGPDGP LYKVSVTARD DVPFFGPPLP DPAVFRKGPE 360
FQEFLLTKLI NAEYACYKAE KFAKLEERTR AALLETLYEE LHIHSQSMMG LGGDEDKMEN 420
GSGGGGFFES FKRVIRSRSQ SMDAMGLSNK KPNTVSTSHS GSFAPNNPDL AKAAGISLIV 480
PGKSPTRKKS GPFGSRRSSA IGIENIQEVQ EKRESPPAGQ KTPDSGHVSQ EPKSENSSTQ 540
SSPEMPTTKN RAETAAQRAE ALKDFSRSSS SASSFASVVE ETEGVDGEDT GLESVSSSGT 600
PHKRDSFIYS TWLEDSVSTT SGGSSPGPSR SPHPDAGKLG DPACPEIKIQ LEASEQHMPQ 660
LGC 663 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0005096; F:GTPase activator activity; TAS:ProtInc.
 GO:0003924; F:GTPase activity; NAS:UniProtKB.
 GO:0032318; P:regulation of Ras GTPase activity; IDA:UniProtKB.
 GO:0007165; P:signal transduction; NAS:UniProtKB. 
Interpro
 IPR003109; GoLoco_motif.
 IPR000331; Rap_GAP_dom. 
Pfam
 PF02188; GoLoco
 PF02145; Rap_GAP 
SMART
 SM00390; GoLoco 
PROSITE
 PS50877; GOLOCO
 PS50085; RAPGAP 
PRINTS