| Tag | Content |
|---|
| CPLM ID | CPLM-021885 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | AP-3 complex subunit beta-2 |
Protein Synonyms/Alias | Adapter-related protein complex 3 subunit beta-2; Adaptor protein complex AP-3 subunit beta-2; Beta-3B-adaptin; Clathrin assembly protein complex 3 beta-2 large chain |
Gene Name | Ap3b2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 37 | GIFSSDYKRHDDLKE | ubiquitination | [1] | | 189 | QLIEVIEKLLADKTT | ubiquitination | [1] | | 517 | EYCEHVPKIAPDVLR | ubiquitination | [1] | | 554 | KLYLTNSKQTKLLTQ | ubiquitination | [1] | | 601 | ALSRHAKKLFLAPKP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. |
Sequence Annotation | MOD_RES 272 272 Phosphoserine.
MOD_RES 282 282 Phosphoserine. |
Keyword | Complete proteome; Cytoplasmic vesicle; Endocytosis; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1082 AA |
Protein Sequence | MSAAPAYSED KGGSAGPGEP EYGHDPASGG IFSSDYKRHD DLKEMLDTNK DSLKLEAMKR 60
IVAMIARGKN ASDLFPAVVK NVACKNIEVK KLVYVYLVRY AEEQQDLALL SISTFQRGLK 120
DPNQLIRASA LRVLSSIRVP IIVPIMMLAI KEAASDMSPY VRKTAAHAIP KLYSLDSDQK 180
DQLIEVIEKL LADKTTLVAG SVVMAFEEVC PERIDLIHKN YRKLCNLLID VEEWGQVVII 240
SMLTRYARTQ FLSPTQNESL LEENPEKAFY GSEEDEAKGP GSEEAATAAL PARKPYVMDP 300
DHRLLLRNTK PLLQSRSAAV VMAVAQLYFH LAPKAEVGVI AKALVRLLRS HSEVQYVVLQ 360
NVATMSIKRR GMFEPYLKSF YIRSTDPTQI KILKLEVLTN LANETNIPTV LREFQTYIRS 420
MDKDFVAATI QAIGRCATNI GRVRDTCLNG LVQLLSNRDE LVVAESVVVI KKLLQMQPAQ 480
HGEIIKHLAK LTDNIQVPMA RASILWLIGE YCEHVPKIAP DVLRKMAKSF TAEEDIVKLQ 540
VINLAAKLYL TNSKQTKLLT QYVLSLAKYD QNYDIRDRAR FTRQLIVPSE QGGALSRHAK 600
KLFLAPKPAP ILESSFKDRD HFQLGSLSHL LNAKATGYQE LPDWPEEAPD PSVRNVEVPE 660
WTKCSNREKR KEKEKPFYSD SEGESGPTES ADSEPESESE SESKSSSGSG SGESSSESDN 720
EEEDEEKGGG SESEQSEEED EKKKKTKKKK ASEGHREGSS SEEGSDSSSS SESEVTSESE 780
EEQVEPASWR KKTPPGSKSA PVAKEISLLD LEDFTPPSVQ PVSPPMVVST SLAADLEGLT 840
LTDSSLVPSL LSPVSSIGRQ ELLHRVAGEG LSVDYAFSRQ PFSGDPHMVS LHIYFSNNSE 900
TPIKGLHVGT PKLPAGISIQ EFPEIESLAP GESTTTVMGI NFCDSTQAAN FQLCTQTRQF 960
YVSIQPPVGE LMAPVFMSEN EFKKEQGKLT GMNEITEKLT LPDTCRSDHM VVQKVTATAN 1020
LGRVPCGTSD EYRFAGRTLT SGSLVLLTLD ARAAGAAQLT VNSEKMVIGT MLVKDVIQAL 1080
TQ 1082 |
Gene Ontology | GO:0030123; C:AP-3 adaptor complex; IEA:InterPro. GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell. GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:Compara. GO:0005802; C:trans-Golgi network; TAS:MGI. GO:0008089; P:anterograde axon cargo transport; IMP:UniProtKB. GO:0048490; P:anterograde synaptic vesicle transport; IMP:UniProtKB. GO:0006897; P:endocytosis; IEA:UniProtKB-KW. GO:0006886; P:intracellular protein transport; TAS:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |