UniProt Accession

 ATP8_HUMAN; P03928; Q34771 

Genbank Protein ID

 J01415; V00662; D38112; AY339402; AY339403; AY339404; AY339405; AY339406; AY339407; AY339408; AY339409; AY339410; AY339411; AY339412; AY339413; AY339414; AY339415; AY339416; AY339417; AY339418; AY339419; AY339420; AY339421; AY339422; AY339423; AY339424; AY339425; AY339426; AY339427; AY339428; AY339429; AY339430; AY339431; AY339432; AY339433; AY339434; AY339435; AY339436; AY339437; AY339438; AY339439; AY339440; AY339441; AY339442; AY339443; AY339444; AY339445; AY339446; AY339447; AY339448; AY339449; AY339450; AY339451; AY339452; AY339453; AY339454; AY339455; AY339456; AY339457; AY339458; AY339459; AY339460; AY339461; AY339462; AY339463; AY339464; AY339465; AY339466; AY339467; AY339468; AY339469; AY339470; AY339471; AY339472; AY339473; AY339474; AY339475; AY339476; AY339477; AY339478; AY339479; AY339480; AY339481; AY339482; AY339483; AY339484; AY339485; AY339486; AY339487; AY339488; AY339489; AY339490; AY339491; AY339492; AY339493; AY339494; AY339495; AY339496; AY339497; AY339498; AY339499; AY339500; AY339501; AY339502; AY339503; AY339504; AY339505; AY339506; AY339507; AY339508; AY339509; AY339510; AY339511; AY339512; AY339513; AY339515; AY339516; AY339517; AY339518; AY339519; AY339520; AY339521; AY339522; AY339523; AY339524; AY339525; AY339526; AY339527; AY339528; AY339529; AY339530; AY339531; AY339532; AY339533; AY339534; AY339535; AY339536; AY339537; AY339538; AY339539; AY339540; AY339541; AY339542; AY339543; AY339544; AY339545; AY339546; AY339547; AY339548; AY339549; AY339550; AY339551; AY339552; AY339553; AY339554; AY339555; AY339556; AY339557; AY339558; AY339559; AY339560; AY339561; AY339562; AY339563; AY339564; AY339565; AY339566; AY339567; AY339568; AY339569; AY339570; AY339571; AY339572; AY339573; AY339574; AY339575; AY339576; AY339577; AY339578; AY339579; AY339580; AY339581; AY339582; AY339583; AY339584; AY339585; AY339586; AY339587; AY339588; AY339589; AY339590; AY339591; AY339592; AY339593; AF346963; AF346964; AF346965; AF346966; AF346967; AF346968; AF346969; AF346970; AF346971; AF346972; AF346973; AF346974; AF346975; AF346976; AF346977; AF346978; AF346979; AF346980; AF346981; AF346982; AF346983; AF346985; AF346986; AF346987; AF346988; AF346991; AF346992; AF346993; AF346994; AF346995; AF346996; AF346997; AF347000; AF347001; AF347002; AF347003; AF347004; AF347005; AF347006; AF347007; AF347008; AF347009; AF347011; AF347012; AF347013; AF347014; AF347015; AY289051; AY289052; AY289053; AY289056; AY289057; AY289058; AY289059; AY289060; AY289061; AY289062; AY289063; AY289064; AY289065; AY289066; AY289067; AY289068; AY289069; AY289070; AY289071; AY289072; AY289073; AY289074; AY289075; AY289076; AY289077; AY289078; AY289080; AY289081; AY289082; AY289083; AY289084; AY289085; AY289086; AY289087; AY289088; AY289089; AY289090; AY289091; AY289092; AY289093; AY289094; AY289095; AY289096; AY289097; AY289098; AY289099; AY289100; AY289101; AY289102; AY495090; AY495091; AY495092; AY495093; AY495094; AY495095; AY495096; AY495097; AY495098; AY495099; AY495100; AY495101; AY495102; AY495103; AY495104; AY495105; AY495106; AY495107; AY495108; AY495109; AY495110; AY495111; AY495112; AY495113; AY495114; AY495115; AY495116; AY495117; AY495118; AY495119; AY495120; AY495121; AY495122; AY495124; AY495125; AY495126; AY495127; AY495128; AY495129; AY495130; AY495131; AY495132; AY495133; AY495134; AY495135; AY495136; AY495137; AY495138; AY495139; AY495140; AY495141; AY495142; AY495143; AY495144; AY495145; AY495146; AY495147; AY495148; AY495149; AY495150; AY495151; AY495152; AY495153; AY495154; AY495155; AY495156; AY495157; AY495158; AY495159; AY495160; AY495161; AY495162; AY495163; AY495164; AY495165; AY495166; AY495167; AY495168; AY495169; AY495170; AY495171; AY495172; AY495173; AY495174; AY495175; AY495176; AY495177; AY495178; AY495179; AY495180; AY495181; AY495182; AY495183; AY495184; AY495185; AY495186; AY495187; AY495188; AY495189; AY495190; AY495191; AY495192; AY495193; AY495194; AY495195; AY495196; AY495197; AY495198; AY495199; AY495200; AY495201; AY495202; AY495203; AY495204; AY495205; AY495206; AY495207; AY495208; AY495209; AY495210; AY495211; AY495212; AY495213; AY495214; AY495215; AY495216; AY495217; AY495218; AY495219; AY495220; AY495221; AY495222; AY495223; AY495224; AY495225; AY495227; AY495228; AY495229; AY495230; AY495231; AY495232; AY495233; AY495234; AY495235; AY495236; AY495237; AY495238; AY495239; AY495240; AY495241; AY495242; AY495243; AY495244; AY495245; AY495246; AY495247; AY495248; AY495249; AY495250; AY495251; AY495252; AY495253; AY495254; AY495255; AY495256; AY495257; AY495259; AY495260; AY495261; AY495262; AY495263; AY495264; AY495265; AY495266; AY495267; AY495268; AY495269; AY495270; AY495271; AY495272; AY495273; AY495274; AY495275; AY495277; AY495278; AY495279; AY495280; AY495281; AY495282; AY495284; AY495285; AY495286; AY495287; AY495288; AY495289; AY495290; AY495291; AY495292; AY495293; AY495294; AY495295; AY495296; AY495297; AY495298; AY495299; AY495301; AY495302; AY495304; AY495305; AY495306; AY495307; AY495308; AY495309; AY495310; AY495311; AY495312; AY495313; AY495314; AY495315; AY495316; AY495317; AY495318; AY495319; AY495320; AY495322; AY495323; AY495324; AY495325; AY495326; AY495327; AY495328; AY495329; AY495330 

Genbank Nucleotide ID

 AAB58947.1; CAA24030.1; BAA07294.1; AAP89040.1; AAP89053.1; AAP89066.1; AAP89079.1; AAP89092.1; AAP89105.1; AAP89118.1; AAP89131.1; AAP89144.1; AAP89157.1; AAP89170.1; AAP89183.1; AAP89196.1; AAP89209.1; AAP89222.1; AAP89235.1; AAP89248.1; AAP89261.1; AAP89274.1; AAP89287.1; AAP89300.1; AAP89313.1; AAP89326.1; AAP89339.1; AAP89352.1; AAP89365.1; AAP89378.1; AAP89391.1; AAP89404.1; AAP89417.1; AAP89430.1; AAP89443.1; AAP89456.1; AAP89469.1; AAP89482.1; AAP89495.1; AAP89508.1; AAP89521.1; AAP89534.1; AAP89547.1; AAP89560.1; AAP89573.1; AAP89586.1; AAP89599.1; AAP89612.1; AAP89625.1; AAP89638.1; AAP89651.1; AAP89664.1; AAP89677.1; AAP89690.1; AAP89703.1; AAP89716.1; AAP89729.1; AAP89742.1; AAP89755.1; AAP89768.1; AAP89781.1; AAP89794.1; AAP89807.1; AAP89820.1; AAP89833.1; AAP89846.1; AAP89859.1; AAP89872.1; AAP89885.1; AAP89898.1; AAP89911.1; AAP89924.1; AAP89937.1; AAP89950.1; AAP89963.1; AAP89976.1; AAP89989.1; AAP90002.1; AAP90015.1; AAP90028.1; AAP90041.1; AAP90054.1; AAP90067.1; AAP90080.1; AAP90093.1; AAP90106.1; AAP90119.1; AAP90132.1; AAP90145.1; AAP90158.1; AAP90171.1; AAP90184.1; AAP90197.1; AAP90210.1; AAP90223.1; AAP90236.1; AAP90249.1; AAP90262.1; AAP90275.1; AAP90288.1; AAP90301.1; AAP90314.1; AAP90327.1; AAP90340.1; AAP90353.1; AAP90366.1; AAP90379.1; AAP90392.1; AAP90405.1; AAP90418.1; AAP90431.1; AAP90444.1; AAP90457.1; AAP90470.1; AAP90483.2; AAP90509.1; AAP90522.1; AAP90535.1; AAP90548.1; AAP90561.1; AAP90574.1; AAP90587.1; AAP90600.1; AAP90613.1; AAP90626.1; AAP90639.1; AAP90652.1; AAP90665.1; AAP90678.1; AAP90691.1; AAP90704.1; AAP90717.1; AAP90730.1; AAP90743.1; AAP90756.1; AAP90769.1; AAP90782.1; AAP90795.1; AAP90808.1; AAP90821.1; AAP90834.1; AAP90847.1; AAP90860.1; AAP90873.1; AAP90886.1; AAP90899.1; AAP90912.1; AAP90925.1; AAP90938.1; AAP90951.1; AAP90964.1; AAP90977.1; AAP90990.1; AAP91003.1; AAP91016.1; AAP91029.1; AAP91042.1; AAP91055.1; AAP91068.1; AAP91081.1; AAP91094.1; AAP91107.1; AAP91120.1; AAP91133.1; AAP91146.1; AAP91159.1; AAP91172.1; AAP91185.1; AAP91198.1; AAP91211.1; AAP91224.1; AAP91237.1; AAP91250.1; AAP91263.1; AAP91276.1; AAP91289.1; AAP91302.1; AAP91315.1; AAP91328.1; AAP91341.1; AAP91354.1; AAP91367.1; AAP91380.1; AAP91393.1; AAP91406.1; AAP91419.1; AAP91432.1; AAP91445.1; AAP91458.1; AAP91471.1; AAP91484.1; AAP91497.1; AAP91510.1; AAP91523.1; AAK17211.1; AAK17224.1; AAK17237.1; AAK17250.1; AAK17263.1; AAK17276.1; AAK17289.1; AAK17302.1; AAK17315.1; AAK17328.1; AAK17341.1; AAK17354.1; AAK17367.1; AAK17380.1; AAK17393.1; AAK17406.1; AAK17419.1; AAK17432.1; AAK17445.1; AAK17458.1; AAK17471.1; AAK17497.1; AAK17510.1; AAK17523.1; AAK17536.1; AAK17575.1; AAK17588.1; AAK17601.1; AAK17614.1; AAK17627.1; AAK17640.1; AAK17653.1; AAK17692.1; AAK17705.1; AAK17718.1; AAK17731.1; AAK17744.1; AAK17757.1; AAK17770.1; AAK17783.1; AAK17796.1; AAK17809.1; AAK17835.1; AAK17848.1; AAK17861.1; AAK17874.1; AAK17887.1; AAP47884.1; AAP47897.1; AAP47910.1; AAP47949.1; AAP47962.1; AAP47975.1; AAP47988.1; AAP48001.1; AAP48014.1; AAP48027.1; AAP48040.1; AAP48053.1; AAP48066.1; AAP48079.1; AAP48092.1; AAP48105.1; AAP48118.1; AAP48131.1; AAP48144.1; AAP48157.1; AAP48170.1; AAP48183.1; AAP48196.1; AAP48209.1; AAP48222.1; AAP48235.1; AAP48261.1; AAP48274.1; AAP48287.1; AAP48300.1; AAP48313.1; AAP48326.1; AAP48339.1; AAP48352.1; AAP48365.1; AAP48378.1; AAP48391.1; AAP48404.1; AAP48417.1; AAP48429.1; AAP48442.1; AAP48455.1; AAP48468.1; AAP48481.1; AAP48494.1; AAP48507.1; AAP48520.1; AAP48533.1; AAP48546.1; AAR92500.1; AAR92513.1; AAR92526.1; AAR92539.1; AAR92552.1; AAR92565.1; AAR92578.1; AAR92591.1; AAR92604.1; AAR92617.1; AAR92630.1; AAR92643.1; AAR92656.1; AAR92669.1; AAR92682.1; AAR92695.1; AAR92708.1; AAR92721.1; AAR92734.1; AAR92747.1; AAR92760.1; AAR92773.1; AAR92786.1; AAR92799.1; AAR92812.1; AAR92825.1; AAR92838.1; AAR92851.1; AAR92864.1; AAR92877.1; AAR92890.1; AAR92903.1; AAR92916.1; AAR92942.1; AAR92955.1; AAR92968.1; AAR92981.1; AAR92994.1; AAR93007.1; AAR93020.1; AAR93033.1; AAR93046.1; AAR93059.1; AAR93072.1; AAR93085.1; AAR93098.1; AAR93111.1; AAR93124.1; AAR93137.1; AAR93150.1; AAR93163.1; AAR93176.1; AAR93189.1; AAR93202.1; AAR93215.1; AAR93228.1; AAR93241.1; AAR93254.1; AAR93267.1; AAR93280.1; AAR93293.1; AAR93306.1; AAR93319.1; AAR93332.1; AAR93345.1; AAR93358.1; AAR93371.1; AAR93384.1; AAR93397.1; AAR93410.1; AAR93423.1; AAR93436.1; AAR93449.1; AAR93462.1; AAR93475.1; AAR93488.1; AAR93501.1; AAR93514.1; AAR93527.1; AAR93540.1; AAR93553.1; AAR93566.1; AAR93579.1; AAR93592.1; AAR93605.1; AAR93618.1; AAR93631.1; AAR93644.1; AAR93657.1; AAR93670.1; AAR93683.1; AAR93696.1; AAR93709.1; AAR93722.1; AAR93735.1; AAR93748.1; AAR93761.1; AAR93774.1; AAR93787.1; AAR93800.1; AAR93813.1; AAR93826.1; AAR93839.1; AAR93852.1; AAR93865.1; AAR93878.1; AAR93891.1; AAR93904.1; AAR93917.1; AAR93930.1; AAR93943.1; AAR93956.1; AAR93969.1; AAR93982.1; AAR93995.1; AAR94008.1; AAR94021.1; AAR94034.1; AAR94047.1; AAR94060.1; AAR94073.1; AAR94086.1; AAR94099.1; AAR94112.1; AAR94125.1; AAR94138.1; AAR94151.1; AAR94164.1; AAR94177.1; AAR94190.1; AAR94203.1; AAR94216.1; AAR94229.1; AAR94242.1; AAR94255.1; AAR94281.1; AAR94294.1; AAR94307.1; AAR94320.1; AAR94333.1; AAR94346.1; AAR94359.1; AAR94372.1; AAR94385.1; AAR94398.1; AAR94411.1; AAR94424.1; AAR94437.1; AAR94450.1; AAR94463.1; AAR94476.1; AAR94489.1; AAR94502.1; AAR94515.1; AAR94528.1; AAR94541.1; AAR94554.1; AAR94567.1; AAR94580.1; AAR94593.1; AAR94606.1; AAR94619.1; AAR94632.1; AAR94645.1; AAR94658.1; AAR94671.1; AAR94697.1; AAR94710.1; AAR94723.1; AAR94736.1; AAR94749.1; AAR94762.1; AAR94775.1; AAR94788.1; AAR94801.1; AAR94814.1; AAR94827.1; AAR94840.1; AAR94853.1; AAR94866.1; AAR94879.1; AAR94892.1; AAR94905.1; AAR94931.1; AAR94944.1; AAR94957.1; AAR94970.1; AAR94983.1; AAR94996.1; AAR95022.1; AAR95035.1; AAR95048.1; AAR95061.1; AAR95074.1; AAR95087.1; AAR95100.1; AAR95113.1; AAR95126.1; AAR95139.1; AAR95152.1; AAR95165.1; AAR95178.1; AAR95191.1; AAR95204.1; AAR95217.1; AAR95243.1; AAR95256.1; AAR95282.1; AAR95295.1; AAR95308.1; AAR95321.1; AAR95334.1; AAR95347.1; AAR95360.1; AAR95373.1; AAR95386.1; AAR95399.1; AAR95412.1; AAR95425.1; AAR95438.1; AAR95451.1; AAR95464.1; AAR95477.1; AAR95490.1; AAR95516.1; AAR95529.1; AAR95542.1; AAR95555.1; AAR95568.1; AAR95581.1; AAR95594.1; AAR95607.1; AAR95620.1 

Protein Name

 ATP synthase protein 8 

Protein Synonyms/Alias

 A6L; F-ATPase subunit 8 

Gene Name

 MT-ATP8 

Gene Synonyms/Alias

 ATP8; ATPASE8; MTATP8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
40	YHLPPSPKPMKMKNY	ubiquitination	[1, 2]
49	MKMKNYNKPWEPKWT	acetylation	[3, 4, 5]
54	YNKPWEPKWTKICSL	acetylation	[5]
54	YNKPWEPKWTKICSL	ubiquitination	[1, 2]
57	PWEPKWTKICSLHSL	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity). 

Sequence Annotation

 MOD_RES 54 54 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; ATP synthesis; CF(0); Complete proteome; Disease mutation; Hydrogen ion transport; Ion transport; Membrane; Mitochondrion; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 68 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); NAS:UniProtKB.
 GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
 GO:0022857; F:transmembrane transporter activity; IC:UniProtKB.
 GO:0006200; P:ATP catabolic process; IDA:GOC.
 GO:0042776; P:mitochondrial ATP synthesis coupled proton transport; IC:UniProtKB.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome. 

Interpro

 IPR001421; ATPase_F0-cplx_su8_mt_metazoan. 

Pfam

 PF00895; ATP-synt_8 

SMART

  

PROSITE

  

PRINTS