CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002202
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Exodeoxyribonuclease I 
Protein Synonyms/Alias
 Exonuclease I; DNA deoxyribophosphodiesterase; dRPase 
Gene Name
 sbcB 
Gene Synonyms/Alias
 cpeA; xonA; b2011; JW1993 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
214YLFTHRNKHKLMALIacetylation[1]
216FTHRNKHKLMALIDVacetylation[1]
287RERLYTAKTDLGDNAacetylation[1]
299DNAAVPVKLVHINKCacetylation[1]
401LDITFVDKRIEKLLFacetylation[1]
405FVDKRIEKLLFNYRAacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease AP lyase. 
Sequence Annotation
  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; DNA damage; DNA repair; Exonuclease; Hydrolase; Nuclease; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 475 AA 
Protein Sequence
MMNDGKQQST FLFHDYETFG THPALDRPAQ FAAIRTDSEF NVIGEPEVFY CKPADDYLPQ 60
PGAVLITGIT PQEARAKGEN EAAFAARIHS LFTVPKTCIL GYNNVRFDDE VTRNIFYRNF 120
YDPYAWSWQH DNSRWDLLDV MRACYALRPE GINWPENDDG LPSFRLEHLT KANGIEHSNA 180
HDAMADVYAT IAMAKLVKTR QPRLFDYLFT HRNKHKLMAL IDVPQMKPLV HVSGMFGAWR 240
GNTSWVAPLA WHPENRNAVI MVDLAGDISP LLELDSDTLR ERLYTAKTDL GDNAAVPVKL 300
VHINKCPVLA QANTLRPEDA DRLGINRQHC LDNLKILREN PQVREKVVAI FAEAEPFTPS 360
DNVDAQLYNG FFSDADRAAM KIVLETEPRN LPALDITFVD KRIEKLLFNY RARNFPGTLD 420
YAEQQRWLEH RRQVFTPEFL QGYADELQML VQQYADDKEK VALLKALWQY AEEIV 475 
Gene Ontology
 GO:0008852; F:exodeoxyribonuclease I activity; IDA:EcoCyc.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0006308; P:DNA catabolic process; IDA:EcoCyc.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW. 
Interpro
 IPR023607; Exodeoxyribonuclease_I.
 IPR013620; Exonuc_X-T_C.
 IPR013520; Exonuclease_RNaseT/DNA_pol3.
 IPR012337; RNaseH-like_dom. 
Pfam
 PF08411; Exonuc_X-T_C
 PF00929; RNase_T 
SMART
  
PROSITE
  
PRINTS