CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036044
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 NAD(P) transhydrogenase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 NNT 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
55VKPGIPYKQLTVGVPubiquitination[1]
70KEIFQNEKRVALSPAacetylation[2, 3, 4]
100SGAGEASKFSDDHYRacetylation[4]
117GAQIQGAKEVLASDLacetylation[3]
166QNPELLNKLSQRKTTacetylation[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 217 AA 
Protein Sequence
MANLLKTVVT GCSCPLLSNL GSCKGLRVKK DFLRTFYTHQ ELWCKAPVKP GIPYKQLTVG 60
VPKEIFQNEK RVALSPAGVQ NLVKQGFNVV VESGAGEASK FSDDHYRVAG AQIQGAKEVL 120
ASDLVVKVRA PMVNPTLGVH EADLLKTSGT LISFIYPAQN PELLNKLSQR KTTVLAMDQV 180
PRVTIAQGYD ALSSMANIAG YKAVVLAANH FGRFFTG 217 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0016491; F:oxidoreductase activity; IEA:InterPro. 
Interpro
 IPR008142; Ala_DH/PNT_CS1.
 IPR007886; AlaDH/PNT_N. 
Pfam
 PF05222; AlaDh_PNT_N 
SMART
 SM01003; AlaDh_PNT_N 
PROSITE
 PS00836; ALADH_PNT_1 
PRINTS