UniProt Accession

 ERPA_ECOLI; P0ACC3; P37026 

Genbank Protein ID

 U70214; U00096; AP009048 

Genbank Nucleotide ID

 AAB08586.1; AAC73267.1; BAB96733.1 

Protein Name

 Iron-sulfur cluster insertion protein ErpA 

Protein Synonyms/Alias

  

Gene Name

 erpA 

Gene Synonyms/Alias

 yadR; b0156; JW0152 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
32	DEDNPNLKLRVYITG	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Probably involved in the insertion of Fe-S clusters into apoproteins in vivo including IspG and/or IspH. Essential for growth under aerobic conditions and for anaerobic respiration but not for fermentation. In vitro it binds Fe-S clusters and transfers them to apo-IspG, which is involved in quinone biosynthesis among many other cell components. Experiments indicate that it is probably also involved in the insertion of other Fe-S clusters than IspG/IspH. 

Sequence Annotation

 METAL 42 42 Iron-sulfur (Probable).
 METAL 106 106 Iron-sulfur (Probable).
 METAL 108 108 Iron-sulfur (Probable).  

Keyword

 Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 114 AA 

Protein Sequence

Gene Ontology

 GO:0051537; F:2 iron, 2 sulfur cluster binding; IDA:EcoCyc.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IDA:EcoCyc.
 GO:0005506; F:iron ion binding; IEA:HAMAP.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0009060; P:aerobic respiration; IMP:EcoCyc.
 GO:0009061; P:anaerobic respiration; IMP:EcoCyc.
 GO:0016226; P:iron-sulfur cluster assembly; IDA:EcoCyc.
 GO:0051604; P:protein maturation; IDA:EcoCyc. 

Interpro

 IPR000361; FeS_biogenesis.
 IPR016092; FeS_cluster_insertion.
 IPR017870; FeS_cluster_insertion_CS.
 IPR023063; FeS_cluster_insertion_RrpA. 

Pfam

 PF01521; Fe-S_biosyn 

SMART

  

PROSITE

 PS01152; HESB 

PRINTS