CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004133
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Secretogranin-2 
Protein Synonyms/Alias
 Chromogranin-C; Secretogranin II; SgII; Secretoneurin; SN 
Gene Name
 SCG2 
Gene Synonyms/Alias
 CHGC 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
38QRNQLLQKEPDLRLEubiquitination[1]
49LRLENVQKFPSPEMIacetylation[2]
49LRLENVQKFPSPEMIubiquitination[1]
461PNPYNQEKVLPRLPYubiquitination[1]
525IINSNQVKRVPGQGSubiquitination[1]
601LEYLNQEKAEKGREHubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 
Functional Description
 Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides. 
Sequence Annotation
 REGION 182 200 O-glycosylated at one site.
 MOD_RES 151 151 Sulfotyrosine.  
Keyword
 Calcium; Cleavage on pair of basic residues; Complete proteome; Glycoprotein; Polymorphism; Reference proteome; Secreted; Signal; Sulfation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 617 AA 
Protein Sequence
MAEAKTHWLG AALSLIPLIF LISGAEAASF QRNQLLQKEP DLRLENVQKF PSPEMIRALE 60
YIENLRQQAH KEESSPDYNP YQGVSVPLQQ KENGDESHLP ERDSLSEEDW MRIILEALRQ 120
AENEPQSAPK ENKPYALNSE KNFPMDMSDD YETQQWPERK LKHMQFPPMY EENSRDNPFK 180
RTNEIVEEQY TPQSLATLES VFQELGKLTG PNNQKRERMD EEQKLYTDDE DDIYKANNIA 240
YEDVVGGEDW NPVEEKIESQ TQEEVRDSKE NIEKNEQIND EMKRSGQLGI QEEDLRKESK 300
DQLSDDVSKV IAYLKRLVNA AGSGRLQNGQ NGERATRLFE KPLDSQSIYQ LIEISRNLQI 360
PPEDLIEMLK TGEKPNGSVE PERELDLPVD LDDISEADLD HPDLFQNRML SKSGYPKTPG 420
RAGTEALPDG LSVEDILNLL GMESAANQKT SYFPNPYNQE KVLPRLPYGA GRSRSNQLPK 480
AAWIPHVENR QMAYENLNDK DQELGEYLAR MLVKYPEIIN SNQVKRVPGQ GSSEDDLQEE 540
EQIEQAIKEH LNQGSSQETD KLAPVSKRFP VGPPKNDDTP NRQYWDEDLL MKVLEYLNQE 600
KAEKGREHIA KRAMENM 617 
Gene Ontology
 GO:0005615; C:extracellular space; IDA:HGNC.
 GO:0030141; C:secretory granule; IEA:InterPro.
 GO:0042056; F:chemoattractant activity; IDA:HGNC.
 GO:0005125; F:cytokine activity; IDA:HGNC.
 GO:0001525; P:angiogenesis; IDA:HGNC.
 GO:0043542; P:endothelial cell migration; TAS:HGNC.
 GO:0048245; P:eosinophil chemotaxis; IDA:HGNC.
 GO:0050930; P:induction of positive chemotaxis; IDA:HGNC.
 GO:0006954; P:inflammatory response; TAS:HGNC.
 GO:0000165; P:MAPK cascade; IDA:HGNC.
 GO:0043066; P:negative regulation of apoptotic process; IDA:HGNC.
 GO:0001937; P:negative regulation of endothelial cell proliferation; TAS:HGNC.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:HGNC.
 GO:0009306; P:protein secretion; TAS:ProtInc. 
Interpro
 IPR018054; Chromogranin_CS.
 IPR001990; Granin. 
Pfam
 PF01271; Granin 
SMART
  
PROSITE
 PS00422; GRANINS_1 
PRINTS