UniProt Accession

 CENPS_HUMAN; Q8N2Z9; Q8NFE5; Q8NFG5 

Genbank Protein ID

 AF516753; AF521016; AL139424; AL354956; AL354956; AL139424; AL139424; AL354956; AL354956; AL139424; AL139424; AL354956; AL354956; AL139424; BC029430 

Genbank Nucleotide ID

 AAM61954.1; AAM70482.1; CAI95756.1; CAI95756.1; CAI19200.1; CAI19200.1; CAI95757.1; CAI95757.1; CAI19201.1; CAI19201.1; CAI95755.1; CAI95755.1; CAI19199.1; CAI19199.1; AAH29430.1 

Protein Name

 Centromere protein S 

Protein Synonyms/Alias

 CENP-S; Apoptosis-inducing TAF9-like domain-containing protein 1; FANCM-interacting histone fold protein 1; Fanconi anemia-associated polypeptide of 16 kDa 

Gene Name

 APITD1 

Gene Synonyms/Alias

 CENPS; FAAP16; MHF1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
94	RRSNSLLKYITDKSE	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. 

Sequence Annotation

  

Keyword

 3D-structure; Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; DNA damage; DNA repair; DNA-binding; Fanconi anemia; Kinetochore; Mitosis; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 138 AA 

Protein Sequence

Gene Ontology

 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0071821; C:FANCM-MHF complex; IDA:UniProtKB.
 GO:0043240; C:Fanconi anaemia nuclear complex; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IDA:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0031398; P:positive regulation of protein ubiquitination; TAS:UniProtKB.
 GO:0031297; P:replication fork processing; IMP:UniProtKB.
 GO:0000712; P:resolution of meiotic recombination intermediates; IMP:UniProtKB. 

Interpro

 IPR009072; Histone-fold.
 IPR003162; TFIID-31. 

Pfam

 PF02291; TFIID-31kDa 

SMART

  

PROSITE

  

PRINTS