UniProt Accession

 AT5F1_RAT; P19511 

Genbank Protein ID

 M35052; BC063808 

Genbank Nucleotide ID

 AAA42187.1; AAH63808.1 

Protein Name

 ATP synthase subunit b, mitochondrial 

Protein Synonyms/Alias

 ATPase subunit b 

Gene Name

 Atp5f1 

Gene Synonyms/Alias

 Atp5f 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
126	SIGEFIDKLNEEKIA	acetylation	[1]
131	IDKLNEEKIAQLEEI	acetylation	[1]
139	IAQLEEIKQSSMKQI	acetylation	[1]
144	EIKQSSMKQIQDAIN	acetylation	[1]
154	QDAINREKAQQALVQ	acetylation	[1]
162	AQQALVQKRHYLFDV	acetylation	[1]
188	TYRERLHKAYKEVKN	acetylation	[1]
194	HKAYKEVKNRLDYHI	acetylation	[1]
210	VQDMMRRKEGEHMIN	acetylation	[1]
221	HMINWVEKHVIQSIS	acetylation	[1]
233	SISAQQEKETIAKCI	acetylation	[1]
238	QEKETIAKCIGDLKM	acetylation	[1]
244	AKCIGDLKMLAKKAQ	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. 

Sequence Annotation

 MOD_RES 115 115 N6-acetyllysine (By similarity).
 MOD_RES 131 131 N6-acetyllysine (By similarity).
 MOD_RES 162 162 N6-acetyllysine (By similarity).
 MOD_RES 188 188 N6-acetyllysine (By similarity).
 MOD_RES 221 221 N6-acetyllysine (By similarity).
 MOD_RES 233 233 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; CF(0); Complete proteome; Hydrogen ion transport; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 256 AA 

Protein Sequence

Gene Ontology

 GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IDA:RGD.
 GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IBA:RefGenome.
 GO:0015986; P:ATP synthesis coupled proton transport; IBA:RefGenome. 

Interpro

 IPR008688; ATPase_B_chain/sub_B/MI25.
 IPR013837; ATPase_F0_sub_B/B_chain. 

Pfam

 PF05405; Mt_ATP-synt_B 

SMART

  

PROSITE

  

PRINTS