CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009443
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 40S ribosomal protein S8 
Protein Synonyms/Alias
  
Gene Name
 Rps8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
37GRPAANTKIGPRRIHacetylation[1]
37GRPAANTKIGPRRIHubiquitination[2]
98VRTKTLVKNCIVLIDacetylation[3]
128LGRKKGAKLTPEEEEacetylation[1, 4, 5, 6]
128LGRKKGAKLTPEEEEsuccinylation[1]
128LGRKKGAKLTPEEEEubiquitination[2]
139EEEEILNKKRSKKIQacetylation[6]
157DERKKNAKISSLLEEacetylation[1, 6]
157DERKKNAKISSLLEEsuccinylation[1]
157DERKKNAKISSLLEEubiquitination[2]
170EEQFQQGKLLACIASacetylation[3]
193DGYVLEGKELEFYLRacetylation[5]
193DGYVLEGKELEFYLRubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
  
Sequence Annotation
 MOD_RES 160 160 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 208 AA 
Protein Sequence
MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG GNKKYRALRL 60
DVGNFSWGSE CCTRKTRIID VVYNASNNEL VRTKTLVKNC IVLIDSTPYR QWYESHYALP 120
LGRKKGAKLT PEEEEILNKK RSKKIQKKYD ERKKNAKISS LLEEQFQQGK LLACIASRPG 180
QCGRADGYVL EGKELEFYLR KIKARKGK 208 
Gene Ontology
 GO:0022627; C:cytosolic small ribosomal subunit; IEA:Compara.
 GO:0030529; C:ribonucleoprotein complex; ISS:UniProtKB.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0006412; P:translation; IEA:InterPro. 
Interpro
 IPR001047; Ribosomal_S8e.
 IPR022309; Ribosomal_S8e/biogenesis_NSA2.
 IPR018283; Ribosomal_S8e_CS. 
Pfam
 PF01201; Ribosomal_S8e 
SMART
  
PROSITE
 PS01193; RIBOSOMAL_S8E 
PRINTS