UniProt Accession

 KPYR_RAT; P12928; P04763; Q64618 

Genbank Protein ID

 M17091; M17088; M17089; M17090; M17091; M17088; M17089; M17090; M17685; X05684; M11709 

Genbank Nucleotide ID

 AAA41882.1; AAA41882.1; AAA41882.1; AAA41882.1; AAA41883.1; AAA41883.1; AAA41883.1; AAA41883.1; AAA41881.1; CAA29169.1; AAA41880.1 

Protein Name

 Pyruvate kinase PKLR 

Protein Synonyms/Alias

 L-PK; Pyruvate kinase isozymes L/R 

Gene Name

 Pklr 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
190	VLVTVDPKFQTRGDA	acetylation	[1]
541	QFGIESGKLRGFLRV	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Plays a key role in glycolysis (By similarity). 

Sequence Annotation

 REGION 475 480 Allosteric activator binding (By
 REGION 559 564 Allosteric activator binding (By
 METAL 118 118 Potassium (By similarity).
 METAL 120 120 Potassium (By similarity).
 METAL 156 156 Potassium (By similarity).
 METAL 157 157 Potassium; via carbonyl oxygen (By
 METAL 315 315 Magnesium (By similarity).
 METAL 339 339 Magnesium (By similarity).
 BINDING 116 116 Substrate (By similarity).
 BINDING 338 338 Substrate; via amide nitrogen (By
 BINDING 339 339 Substrate; via amide nitrogen (By
 BINDING 371 371 Substrate (By similarity).
 BINDING 525 525 Allosteric activator (By similarity).
 BINDING 532 532 Allosteric activator (By similarity).  

Keyword

 Allosteric enzyme; Alternative splicing; ATP-binding; Complete proteome; Glycolysis; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Potassium; Pyruvate; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 574 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0030955; F:potassium ion binding; IEA:InterPro.
 GO:0004743; F:pyruvate kinase activity; IDA:RGD.
 GO:0006754; P:ATP biosynthetic process; IDA:RGD.
 GO:0032869; P:cellular response to insulin stimulus; IDA:RGD.
 GO:0006096; P:glycolysis; IDA:RGD.
 GO:0042866; P:pyruvate biosynthetic process; IDA:RGD.
 GO:0033198; P:response to ATP; IDA:RGD.
 GO:0051591; P:response to cAMP; IDA:RGD.
 GO:0009749; P:response to glucose stimulus; IEP:RGD.
 GO:0009408; P:response to heat; IDA:RGD.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0010226; P:response to lithium ion; IDA:RGD.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0051707; P:response to other organism; IEA:Compara. 

Interpro

 IPR001697; Pyr_Knase.
 IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
 IPR011037; Pyrv_Knase-like_insert_dom.
 IPR015794; Pyrv_Knase_a/b.
 IPR018209; Pyrv_Knase_AS.
 IPR015793; Pyrv_Knase_brl.
 IPR015795; Pyrv_Knase_C.
 IPR015806; Pyrv_Knase_insert_dom. 

Pfam

 PF00224; PK
 PF02887; PK_C 

SMART

  

PROSITE

 PS00110; PYRUVATE_KINASE 

PRINTS

 PR01050; PYRUVTKNASE.