CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019215
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HSPB1-associated protein 1 
Protein Synonyms/Alias
 27 kDa heat shock protein-associated protein 1; Protein associated with small stress protein 1 
Gene Name
 HSPBAP1 
Gene Synonyms/Alias
 PASS1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26GEEGEHVKPFKPEKAubiquitination[1]
147TDLFQDVKWSDFGFPubiquitination[2]
219EESSVFSKINVVNPDubiquitination[1, 2]
228NVVNPDLKRFPQFRKubiquitination[1, 2, 3]
296RMLVCALKTAENPQNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
 May play a role in cellular stress response (By similarity). 
Sequence Annotation
 DOMAIN 124 288 JmjC.
 REGION 88 208 Interaction with HSPB1 (By similarity).  
Keyword
 Alternative splicing; Chromosomal rearrangement; Complete proteome; Cytoplasm; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 488 AA 
Protein Sequence
MAAGSEATTP VIVAAGAGGE EGEHVKPFKP EKAKEIIMSL QQPAIFCNMV FDWPARHWNA 60
KYLSQVLHGK QIRFRMGMKS MSTVPQFETT CNYVEATLEE FLTWNCDQSS ISGPFRDYDH 120
SKFWAYADYK YFVSLFEDKT DLFQDVKWSD FGFPGRNGQE STLWIGSLGA HTPCHLDSYG 180
CNLVFQVQGR KRWHLFPPED TPFLYPTRIP YEESSVFSKI NVVNPDLKRF PQFRKAQRHA 240
VTLSPGQVLF VPRHWWHYVE SIDPVTVSIN SWIELEEDHL ARVEEAITRM LVCALKTAEN 300
PQNTRAWLNP TEVEETSHAV NCCYLNAAVS AFFDRCRTSE VVEIQALRTD GEHMKKEELN 360
VCNHMEVGQT GSQNLTTGTD KPEAASPFGP DLVPVAQRSE EPPSERGGIF GSDGKDFVDK 420
DGEHFGKLHC AKRQQIMSNS ENAIEEQIAS NTTTTPQTFI STDDLLDCLV NPQVTRIVAQ 480
LLIQGRSL 488 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. 
Interpro
 IPR013296; HSPB1-associated_protein_1.
 IPR003347; JmjC_dom. 
Pfam
  
SMART
 SM00558; JmjC 
PROSITE
 PS51184; JMJC 
PRINTS
 PR01886; PASS1.