UniProt Accession

 LDH6A_HUMAN; Q6ZMR3; D3DQY5 

Genbank Protein ID

 AY581313; AK131523; CH471064; CH471064 

Genbank Nucleotide ID

 AAS93432.1; BAD18662.1; EAW68387.1; EAW68388.1 

Protein Name

 L-lactate dehydrogenase A-like 6A 

Protein Synonyms/Alias

  

Gene Name

 LDHAL6A 

Gene Synonyms/Alias

 LDHL2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
155	WKLSGFPKNRVIGSG	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed. 

Sequence Annotation

 NP_BIND 29 57 NAD (By similarity).
 ACT_SITE 193 193 Proton acceptor (By similarity).
 BINDING 99 99 NAD (By similarity).
 BINDING 106 106 Substrate (By similarity).
 BINDING 138 138 NAD or substrate (By similarity).
 BINDING 169 169 Substrate (By similarity).
 BINDING 248 248 Substrate (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 332 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004459; F:L-lactate dehydrogenase activity; IEA:EC.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW. 

Interpro

 IPR001557; L-lactate/malate_DH.
 IPR011304; L-lactate_DH.
 IPR018177; L-lactate_DH_AS.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF02866; Ldh_1_C
 PF00056; Ldh_1_N 

SMART

  

PROSITE

 PS00064; L_LDH 

PRINTS

 PR00086; LLDHDRGNASE.