UniProt Accession

 LRC8A_MOUSE; Q80WG5; A2AQZ0 

Genbank Protein ID

 AL845258; CH466542; BC048152 

Genbank Nucleotide ID

 CAM20568.1; EDL08450.1 

Protein Name

 Leucine-rich repeat-containing protein 8A 

Protein Synonyms/Alias

  

Gene Name

 Lrrc8a 

Gene Synonyms/Alias

 Lrrc8 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
184	VVEESDPKPAFSKMN	ubiquitination	[1]
241	KKEGEQAKALFEKVK	ubiquitination	[1]
501	NLRALHIKFTDIKEI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in B-cell development. Required for the pro-B cell to pre-B cell transition. 

Sequence Annotation

 REPEAT 373 401 LRR 1.
 REPEAT 402 424 LRR 2.
 REPEAT 425 447 LRR 3.
 REPEAT 448 470 LRR 4.
 REPEAT 471 494 LRR 5.
 REPEAT 495 518 LRR 6.
 REPEAT 519 545 LRR 7.
 REPEAT 546 568 LRR 8.
 REPEAT 569 592 LRR 9.
 REPEAT 593 615 LRR 10.
 REPEAT 616 640 LRR 11.
 REPEAT 641 663 LRR 12.
 REPEAT 664 686 LRR 13.
 REPEAT 687 706 LRR 14.
 REPEAT 707 732 LRR 15.
 REPEAT 733 755 LRR 16.
 REPEAT 756 777 LRR 17.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 217 217 Phosphoserine.
 CARBOHYD 83 83 N-linked (GlcNAc...) (Potential).
 CARBOHYD 191 191 N-linked (GlcNAc...) (Potential).
 CARBOHYD 526 526 N-linked (GlcNAc...) (Potential).
 CARBOHYD 554 554 N-linked (GlcNAc...) (Potential).
 CARBOHYD 592 592 N-linked (GlcNAc...) (Potential).
 CARBOHYD 660 660 N-linked (GlcNAc...) (Potential).
 CARBOHYD 696 696 N-linked (GlcNAc...) (Potential).
 CARBOHYD 755 755 N-linked (GlcNAc...) (Potential).  

Keyword

 Acetylation; Complete proteome; Differentiation; Glycoprotein; Leucine-rich repeat; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 810 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0002329; P:pre-B cell differentiation; IMP:UniProtKB. 

Interpro

 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR021040; LRR_protein-8_N. 

Pfam

 PF12534; DUF3733
 PF12799; LRR_4 

SMART

 SM00369; LRR_TYP 

PROSITE

 PS51450; LRR 

PRINTS