CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022609
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 LanC-like protein 1 
Protein Synonyms/Alias
 40 kDa erythrocyte membrane protein; p40 
Gene Name
 Lancl1 
Gene Synonyms/Alias
 Gpr69a 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
15NPYADYNKSLAENYFacetylation[1]
142TRLIHLNKIDPHVPNacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 May play a role in EPS8 signaling. Binds glutathion (By similarity). 
Sequence Annotation
 REGION 364 367 Glutathione binding (By similarity).
 METAL 276 276 Zinc (By similarity).
 METAL 322 322 Zinc (By similarity).
 METAL 323 323 Zinc (By similarity).
 BINDING 317 317 Glutathione (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 142 142 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Membrane; Metal-binding; Nucleus; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 399 AA 
Protein Sequence
MAQRAFPNPY ADYNKSLAEN YFDSTGRLTP EFSHRLTNKI RELLQQMERG LKSADPQDGT 60
GYTGWAGIAV LYLHLHNVFG DPAYLQMAHS YVKHSLNCLS RRSITFLCGD AGPLAVAAVL 120
YHKMNSGKQA EDCITRLIHL NKIDPHVPNE MLYGRIGYIF ALLFVNKNFG EEKIPQSHIQ 180
QICETILTSG EKLSRKRNFT TKSPLMYEWY QEYYVGAAHG LAGIYYYLMQ PSLHVSQGKL 240
HSLVKPSVDF VCQLKFPSGN YPSCLDDTRD LLVHWCHGAP GVIYMLIQAY KVFKEEHYLC 300
DAQQCADVIW QYGLLKKGYG LCHGAAGNAY AFLALYNLTQ DAKYLYRACK FAEWCLDYGE 360
HGCRTPDTPF SLFEGMAGTI YFLADLLVPT KAKFPAFEL 399 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0015630; C:microtubule cytoskeleton; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0043295; F:glutathione binding; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; ISS:UniProtKB.
 GO:0008152; P:metabolic process; IEA:GOC. 
Interpro
 IPR008928; 6-hairpin_glycosidase-like.
 IPR012341; 6hp_glycosidase.
 IPR007822; LANC-like.
 IPR020464; LanC-like_prot_euk. 
Pfam
 PF05147; LANC_like 
SMART
  
PROSITE
  
PRINTS
 PR01951; LANCEUKARYTE.
 PR01950; LANCSUPER.