CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012872
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protogenin 
Protein Synonyms/Alias
 Protein Shen-Dan 
Gene Name
 PRTG 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
977IYRSKARKSSASKTAubiquitination[1]
982ARKSSASKTAQNGTQubiquitination[1, 2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 May play a role in anteroposterior axis elongation (By similarity). 
Sequence Annotation
 DOMAIN 36 130 Ig-like 1.
 DOMAIN 135 222 Ig-like 2.
 DOMAIN 235 322 Ig-like 3.
 DOMAIN 327 411 Ig-like 4.
 DOMAIN 419 512 Fibronectin type-III 1.
 DOMAIN 517 609 Fibronectin type-III 2.
 DOMAIN 615 708 Fibronectin type-III 3.
 DOMAIN 721 815 Fibronectin type-III 4.
 DOMAIN 819 914 Fibronectin type-III 5.
 CARBOHYD 90 90 N-linked (GlcNAc...) (Potential).
 CARBOHYD 488 488 N-linked (GlcNAc...) (Potential).
 CARBOHYD 630 630 N-linked (GlcNAc...) (Potential).
 CARBOHYD 986 986 N-linked (GlcNAc...) (Potential).
 DISULFID 60 113 By similarity.
 DISULFID 156 205 By similarity.
 DISULFID 256 304 By similarity.
 DISULFID 348 395 By similarity.  
Keyword
 Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1150 AA 
Protein Sequence
MAPPLRPLAR LRPPGMLLRA LLLLLLLSPL PGVWCFSELS FVKEPQDVTV TRKDPVVLDC 60
QAHGEVPIKV TWLKNGAKMS ENKRIEVLSN GSLYISEVEG RRGEQSDEGF YQCLAMNKYG 120
AILSQKAHLA LSTISAFEVQ PISTEVHEGG VARFACKISS HPPAVITWEF NRTTLPMTMD 180
RITALPTGVL QIYDVSQRDS GNYRCIAATV AHRRKSMEAS LTVIPAKESK SFHTPTIIAG 240
PQNITTSLHQ TVVLECMATG NPKPIISWSR LDHKSIDVFN TRVLGNGNLM ISDVRLQHAG 300
VYVCRATTPG TRNFTVAMAT LTVLAPPSFV EWPESLTRPR AGTARFVCQA EGIPSPKMSW 360
LKNGRKIHSN GRIKMYNSKL VINQIIPEDD AIYQCMAENS QGSILSRARL TVVMSEDRPS 420
APYNVHAETM SSSAILLAWE RPLYNSDKVI AYSVHYMKAE GLNNEEYQVV IGNDTTHYII 480
DDLEPASNYT FYIVAYMPMG ASQMSDHVTQ NTLEDVPLRP PEISLTSRSP TDILISWLPI 540
PAKYRRGQVV LYRLSFRLST ENSIQVLELP GTTHEYLLEG LKPDSVYLVR ITAATRVGLG 600
ESSVWTSHRT PKATSVKAPK SPELHLEPLN CTTISVRWQQ DVEDTAAIQG YKLYYKEEGQ 660
QENGPIFLDT KDLLYTLSGL DPRRKYHVRL LAYNNIDDGY QADQTVSTPG CVSVRDRMVP 720
PPPPPHHLYA KANTSSSIFL HWRRPAFTAA QIINYTIRCN PVGLQNASLV LYLQTSETHM 780
LVQGLEPNTK YEFAVRLHVD QLSSPWSPVV YHSTLPEAPA GPPVGVKVTL IEDDTALVSW 840
KPPDGPETVV TRYTILYASR KAWIAGEWQV LHREGAITMA LLENLVAGNV YIVKISASNE 900
VGEGPFSNSV ELAVLPKETS ESNQRPKRLD SADAKVYSGY YHLDQKSMTG IAVGVGIALT 960
CILICVLILI YRSKARKSSA SKTAQNGTQQ LPRTSASLAS GNEVGKNLEG AVGNEESLMP 1020
MIMPNSFIDA KGGTDLIINS YGPIIKNNSK KKWFFFQDSK KIQVEQPQRR FTPAVCFYQP 1080
GTTVLISDED SPSSPGQTTS FSRPFGVAAD TEHSANSEGS HETGDSGRFS HESNDEIHLS 1140
SVISTTPPNL 1150 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003598; Ig_sub2. 
Pfam
 PF00041; fn3
 PF07679; I-set 
SMART
 SM00060; FN3
 SM00408; IGc2 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE 
PRINTS