UniProt Accession

 SSR5_HUMAN; P35346; P34988; Q541E0; Q9UJI5 

Genbank Protein ID

 L14865; D16827; AY081193; AE006466; AL031713; CH471112 

Genbank Nucleotide ID

 AAA20828.1; BAA04107.1; AAL88744.1; AAK61266.1; EAW85687.1 

Protein Name

 Somatostatin receptor type 5 

Protein Synonyms/Alias

 SS-5-R; SS5-R; SS5R 

Gene Name

 SSTR5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
363	NGLMQTSKL******	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. 

Sequence Annotation

 MOD_RES 325 325 Phosphoserine; by PKA (Potential).
 LIPID 320 320 S-palmitoyl cysteine; by ZDHHC5 (By
 CARBOHYD 13 13 N-linked (GlcNAc...) (Potential).
 CARBOHYD 26 26 N-linked (GlcNAc...) (Potential).
 CARBOHYD 187 187 N-linked (GlcNAc...) (Potential).
 DISULFID 112 186 By similarity.  

Keyword

 Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 364 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0004994; F:somatostatin receptor activity; TAS:ProtInc.
 GO:0007187; P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
 GO:0050796; P:regulation of insulin secretion; IEA:Compara. 

Interpro

 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM.
 IPR000586; Somatstn_rcpt.
 IPR001184; Somatstn_rcpt_5. 

Pfam

 PF00001; 7tm_1 

SMART

  

PROSITE

 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 

PRINTS

 PR00237; GPCRRHODOPSN.
 PR00246; SOMATOSTATNR.
 PR00591; SOMATOSTTN5R.