UniProt Accession

 SLAF5_HUMAN; Q9UIB8; B2R8T1; B7Z3R8; O15430; O95266; O95660; Q5H9R1; Q6FHA8; Q8WLP1; Q8WWI8; Q9UF04; Q9UIB6; Q9UIB7; Q9UIT7 

Genbank Protein ID

 U82988; AJ223324; AF054815; AF054816; AF054817; AF054818; AF081189; AH008972; AH008376; U96627; Y12632; AK296290; AK313496; CR541847; CR933666; AL138930; AL138930; AL138930; AL138930; AL138930; AL138930; CH471121; BC020063 

Genbank Nucleotide ID

 AAB84364.1; CAA11264.1; AAF21721.1; AAF21722.1; AAF21723.1; AAF21724.1; AAD13155.1; AAF21784.1; AAF06840.1; AAD04232.1; CAA73181.1; BAH12304.1; BAG36278.1; CAG46645.1; CAI45963.1; CAI15158.1; CAI15159.1; CAI15160.1; CAI15161.1; CAI15162.1; CAI15163.1; EAW52707.1; AAH20063.1 

Protein Name

 SLAM family member 5 

Protein Synonyms/Alias

 Cell surface antigen MAX.3; Hly9-beta; Leukocyte differentiation antigen CD84; Signaling lymphocytic activation molecule 5; CD84 

Gene Name

 CD84 

Gene Synonyms/Alias

 SLAMF5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
108	MEDAGDYKADINTQA	ubiquitination	[1]
122	ADPYTTTKRYNLQIY	ubiquitination	[1]
303	YDEILQSKVLPSKEE	ubiquitination	[1]
308	QSKVLPSKEEPVNTV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells. 

Sequence Annotation

 DOMAIN 135 207 Ig-like C2-type.
 MOTIF 277 282 ITSM motif 1.
 MOTIF 314 319 ITSM motif 2.
 MOD_RES 296 296 Phosphotyrosine.
 MOD_RES 316 316 Phosphotyrosine.
 CARBOHYD 150 150 N-linked (GlcNAc...) (Potential).
 DISULFID 155 193 By similarity.  

Keyword

 3D-structure; Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 345 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0004872; F:receptor activity; IEA:InterPro.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0006952; P:defense response; TAS:ProtInc.
 GO:0007156; P:homophilic cell adhesion; TAS:ProtInc.
 GO:0050900; P:leukocyte migration; TAS:Reactome. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR015631; SLAM_fam_rcpts. 

Pfam

  

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS