CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004930
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Catalase HPII 
Protein Synonyms/Alias
 Hydroxyperoxidase II 
Gene Name
 katE 
Gene Synonyms/Alias
 b1732; JW1721 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
64APDTRNEKLNSLEDVacetylation[1]
142HGYFQPYKSLSDITKacetylation[1, 2]
149KSLSDITKADFLSDPacetylation[1]
294TFVRFHWKPLAGKASacetylation[1]
583PPDVNGLKKDPSLSLacetylation[1]
584PDVNGLKKDPSLSLYacetylation[1, 2]
621ADLLAILKALKAKGVacetylation[1, 2]
624LAILKALKAKGVHAKacetylation[1]
693MEAYKHLKPIALAGDacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 
Functional Description
 Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. 
Sequence Annotation
 ACT_SITE 128 128 By similarity.
 ACT_SITE 201 201 By similarity.
 METAL 415 415 Iron (heme axial ligand).
 CROSSLNK 392 415 3'-histidyl-3-tyrosine (His-Tyr).  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 753 AA 
Protein Sequence
MSQHNEKNPH QHQSPLHDSS EAKPGMDSLA PEDGSHRPAA EPTPPGAQPT APGSLKAPDT 60
RNEKLNSLED VRKGSENYAL TTNQGVRIAD DQNSLRAGSR GPTLLEDFIL REKITHFDHE 120
RIPERIVHAR GSAAHGYFQP YKSLSDITKA DFLSDPNKIT PVFVRFSTVQ GGAGSADTVR 180
DIRGFATKFY TEEGIFDLVG NNTPIFFIQD AHKFPDFVHA VKPEPHWAIP QGQSAHDTFW 240
DYVSLQPETL HNVMWAMSDR GIPRSYRTME GFGIHTFRLI NAEGKATFVR FHWKPLAGKA 300
SLVWDEAQKL TGRDPDFHRR ELWEAIEAGD FPEYELGFQL IPEEDEFKFD FDLLDPTKLI 360
PEELVPVQRV GKMVLNRNPD NFFAENEQAA FHPGHIVPGL DFTNDPLLQG RLFSYTDTQI 420
SRLGGPNFHE IPINRPTCPY HNFQRDGMHR MGIDTNPANY EPNSINDNWP RETPPGPKRG 480
GFESYQERVE GNKVRERSPS FGEYYSHPRL FWLSQTPFEQ RHIVDGFSFE LSKVVRPYIR 540
ERVVDQLAHI DLTLAQAVAK NLGIELTDDQ LNITPPPDVN GLKKDPSLSL YAIPDGDVKG 600
RVVAILLNDE VRSADLLAIL KALKAKGVHA KLLYSRMGEV TADDGTVLPI AATFAGAPSL 660
TVDAVIVPCG NIADIADNGD ANYYLMEAYK HLKPIALAGD ARKFKATIKI ADQGEEGIVE 720
ADSADGSFMD ELLTLMAAHR VWSRIPKIDK IPA 753 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0004096; F:catalase activity; IDA:EcoCyc.
 GO:0020037; F:heme binding; IDA:EcoliWiki.
 GO:0042802; F:identical protein binding; IDA:EcoCyc.
 GO:0005506; F:iron ion binding; IDA:EcoliWiki.
 GO:0042744; P:hydrogen peroxide catabolic process; IMP:EcoliWiki.
 GO:0006972; P:hyperosmotic response; IEP:EcoCyc.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki. 
Interpro
 IPR018028; Catalase.
 IPR020835; Catalase-like_dom.
 IPR024708; Catalase_AS.
 IPR024712; Catalase_clade2.
 IPR011614; Catalase_core.
 IPR002226; Catalase_haem_BS.
 IPR010582; Catalase_immune_responsive. 
Pfam
 PF00199; Catalase
 PF06628; Catalase-rel 
SMART
 SM01060; Catalase 
PROSITE
 PS00437; CATALASE_1
 PS00438; CATALASE_2
 PS51402; CATALASE_3 
PRINTS
 PR00067; CATALASE.