| Tag | Content |
|---|
| CPLM ID | CPLM-020399 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tether containing UBX domain for GLUT4 |
Protein Synonyms/Alias | Alveolar soft part sarcoma chromosomal region candidate gene 1 protein; Alveolar soft part sarcoma locus; Renal papillary cell carcinoma protein 17; UBX domain-containing protein 9 |
Gene Name | ASPSCR1 |
Gene Synonyms/Alias | ASPL; RCC17; TUG; UBXD9; UBXN9 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 75 | ANLPNNAKLEMVPAS | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by METTL21D. |
Sequence Annotation | DOMAIN 386 462 UBX.
REGION 317 380 Interaction with GLUT4 (By similarity).
MOD_RES 500 500 Phosphoserine. |
Keyword | Alternative splicing; Chromosomal rearrangement; Complete proteome; Cytoplasm; Membrane; Nucleus; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 553 AA |
Protein Sequence | MAAPAGGGGS AVSVLAPNGR RHTVKVTPST VLLQVLEDTC RRQDFNPCEY DLKFQRSVLD 60
LSLQWRFANL PNNAKLEMVP ASRSREGPEN MVRIALQLDD GSRLQDSFCS GQTLWELLSH 120
FPQIRECLQH PGGATPVCVY TRDEVTGEAA LRGTTLQSLG LTGGSATIRF VMKCYDPVGK 180
TPGSLGSSAS AGQAAASAPL PLESGELSRG DLSRPEDADT SGPCCEHTQE KQSTRAPAAA 240
PFVPFSGGGQ RLGGPPGPTR PLTSSSAKLP KSLSSPGGPS KPKKSKSGQD PQQEQEQERE 300
RDPQQEQERE RPVDREPVDR EPVVCHPDLE ERLQAWPAEL PDEFFELTVD DVRRRLAQLK 360
SERKRLEEAP LVTKAFREAQ IKEKLERYPK VALRVLFPDR YVLQGFFRPS ETVGDLRDFV 420
RSHLGNPELS FYLFITPPKT VLDDHTQTLF QPQLGDRVAP FTLGPSLKRC LGPEQRTRLP 480
VVGDGGDVDS GRLLFWGPSR GRASPSTGQP PCHPVCRPSS PPSPRPSSGD PSRVKAGHKH 540
VGTGRANLFP AALVHLGAEE PAGVYLEPGL LEHAISPSAA DVLVARYMSR AAGSPSPLPA 600
PDPAPKSEPA AEEGALVPPE PIPGTAQPVK RSLGKVPKWL KLPASKR 647 |
Gene Ontology | GO:0005829; C:cytosol; IEA:Compara. GO:0019898; C:extrinsic to membrane; IEA:Compara. GO:0009898; C:internal side of plasma membrane; IEA:Compara. GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara. GO:0012506; C:vesicle membrane; IEA:Compara. GO:0016044; P:cellular membrane organization; TAS:Reactome. GO:0042593; P:glucose homeostasis; IEA:Compara. GO:0006886; P:intracellular protein transport; IEA:Compara. GO:0046324; P:regulation of glucose import; IEA:Compara. |
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