CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037021
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 U4/U6 small nuclear ribonucleoprotein Prp31 
Protein Synonyms/Alias
  
Gene Name
 PRPF31 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
298AARLVAAKCTLAARVubiquitination[1]
321GKVGYELKDEIERKFubiquitination[1]
341PPPVKQVKPLPAPLDacetylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 450 AA 
Protein Sequence
MSLADELLAD LEEAAEEEEG GSYGEEEEEP AIEDVQEETQ LDLSGDSVKT IAKLWDSKMF 60
AEIMMKIEEY ISKQAKASEV MGPVEAAPEY RVIVDANNLT VEIENELNII HKFIRDKYSK 120
RFPELESLVP NALDYIRTVK ELGNSLDKCK NNENLQQILT NATIMVVSVT ASTTQGQQLS 180
EEELERLEEA CDMALELNAS KHRIYEYVES RMSFIAPNLS IIIGASTAAK IMGVAGGLTN 240
LSKMPACNIM LLGAQRKTLS GFSSTSVLPH TGYIYHSDIV QSLPPDLRRK AARLVAAKCT 300
LAARVDSFHE STEGKVGYEL KDEIERKFDK WQEPPPVKQV KPLPAPLDGQ RKKRGGRRYR 360
KMKERLGLTE IRKQANRMSF GEIEEDAYQE DLGFSLGHLD AAADPAEAER RIWREVHHPR 420
PLLGHGLQRG LHPTPGPGDC EPTGGREEGG 450 
Gene Ontology
 GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:InterPro.
 GO:0000244; P:assembly of spliceosomal tri-snRNP; IEA:InterPro. 
Interpro
 IPR002687; Nop_dom.
 IPR012976; NOSIC.
 IPR027105; Prp31.
 IPR019175; Prp31_C. 
Pfam
 PF01798; Nop
 PF08060; NOSIC
 PF09785; Prp31_C 
SMART
 SM00931; NOSIC 
PROSITE
 PS51358; NOP 
PRINTS