CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012748
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lanosterol 14-alpha demethylase 
Protein Synonyms/Alias
 LDM; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase 
Gene Name
 CYP51A1 
Gene Synonyms/Alias
 CYP51 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
22AALLFNSKNEDLNAEubiquitination[1]
42LTTPVFGKGVAYDVPubiquitination[1]
57NPVFLEQKKMLKSGLubiquitination[1]
81SIIEKETKEYFESWGubiquitination[1]
162DRAHREIKDIFYKAIubiquitination[1]
167EIKDIFYKAIQKRRQubiquitination[1]
178KRRQSQEKIDDILQTubiquitination[1]
313PTVNQRLKDSWVERLubiquitination[1]
337DNPASGEKFAYVPFGubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. 
Sequence Annotation
 METAL 449 449 Iron (heme axial ligand).  
Keyword
 3D-structure; Alternative splicing; Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Endoplasmic reticulum; Heme; Iron; Lipid biosynthesis; Lipid metabolism; Membrane; Metal-binding; Microsome; Monooxygenase; NADP; Oxidoreductase; Polymorphism; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 503 AA 
Protein Sequence
MVGKTFTYLL GSDAAALLFN SKNEDLNAED VYSRLTTPVF GKGVAYDVPN PVFLEQKKML 60
KSGLNIAHFK QHVSIIEKET KEYFESWGES GEKNVFEALS ELIILTASHC LHGKEIRSQL 120
NEKVAQLYAD LDGGFSHAAW LLPGWLPLPS FRRRDRAHRE IKDIFYKAIQ KRRQSQEKID 180
DILQTLLDAT YKDGRPLTDD EVAGMLIGLL LAGQHTSSTT SAWMGFFLAR DKTLQKKCYL 240
EQKTVCGENL PPLTYDQLKD LNLLDRCIKE TLRLRPPIMI MMRMARTPQT VAGYTIPPGH 300
QVCVSPTVNQ RLKDSWVERL DFNPDRYLQD NPASGEKFAY VPFGAGRHRC IGENFAYVQI 360
KTIWSTMLRL YEFDLIDGYF PTVNYTTMIH TPENPVIRYK RRSK 404 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IDA:UniProtKB.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0008398; F:sterol 14-demethylase activity; IDA:UniProtKB.
 GO:0006695; P:cholesterol biosynthetic process; TAS:Reactome.
 GO:0033488; P:cholesterol biosynthetic process via 24,25-dihydrolanosterol; IEA:Compara.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002403; Cyt_P450_E_grp-IV. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00465; EP450IV.
 PR00385; P450.