CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012588
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TATA box-binding protein-associated factor RNA polymerase I subunit C 
Protein Synonyms/Alias
 RNA polymerase I-specific TBP-associated factor 110 kDa; TAFI110; TATA box-binding protein-associated factor 1C; TBP-associated factor 1C; Transcription initiation factor SL1/TIF-IB subunit C 
Gene Name
 TAF1C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
124VAFAPLGKLMLENFKubiquitination[1, 2]
131KLMLENFKLEGAGSRubiquitination[1, 2]
258DNPQFLGKPGRIQLQubiquitination[1, 2]
323CAVWKFGKQWQPTLLubiquitination[1, 2]
409VGDRTGVKMLDTQGPubiquitination[2]
434GAEASCQKGERVLLTubiquitination[1, 2]
479LPLVPMLKWNHGLPSubiquitination[2]
552AFPLLEPKIQWRLQEubiquitination[1, 2]
641AGCSQWLKALLKVPLubiquitination[2]
645QWLKALLKVPLAPPVubiquitination[2]
716PESGLEDKLSERLGEubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. 
Sequence Annotation
 MOD_RES 848 848 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 869 AA 
Protein Sequence
MDFPSSLRPA LFLTGPLGLS DVPDLSFMCS WRDALTLPEA QPQNSENGAL HVTKDLLWEP 60
ATPGPLPMLP PLIDPWDPGL TARDLLFRGG CRYRKRPRVV LDVTEQISRF LLDHGDVAFA 120
PLGKLMLENF KLEGAGSRTK KKTVVSVKKL LQDLGGHQPW GCPWAYLSNR QRRFSILGGP 180
ILGTSVASHL AELLHEELVL RWEQLLLDEA CTGGALAWVP GRTPQFGQLV YPAGGAQDRL 240
HFQEVVLTPG DNPQFLGKPG RIQLQGPVRQ VVTCTVQGES KALIYTFLPH WLTCYLTPGP 300
FHPSSALLAV RSDYHCAVWK FGKQWQPTLL QAMQVEKGAT GISLSPHLPG ELAICSRSGA 360
VCLWSPEDGL RQIYRDPETL VFRDSSSWRW ADFTAHPRVL TVGDRTGVKM LDTQGPPGCG 420
LLLFRLGAEA SCQKGERVLL TQYLGHSSPK CLPPTLHLVC TQFSLYLVDE RLPLVPMLKW 480
NHGLPSPLLL ARLLPPPRPS CVQPLLLGGQ GGQLQLLHLA GEGASVPRLA GPPQSLPSRI 540
DSLPAFPLLE PKIQWRLQER LKAPTIGLAA VVPPLPSAPT PGLVLFQLSA AGDVFYQQLR 600
PQVDSSLRRD AGPPGDTQPD CHAPTASWTS QDTAGCSQWL KALLKVPLAP PVWTAPTFTH 660
RQMLGSTELR REEEEGQRLG VLRKAMARGQ LLLQRDLGSL PAAEPPPAPE SGLEDKLSER 720
LGEAWAGRGA AWWERQQGRT SEPGRQTRRP KRRTQLSSSF SLSGHVDPSE DTSSPHSPEW 780
PPADALPLPP TTPPSQELTP DACAQGVPSE QRQMLRDYMA KLPPQRDTPG CATTPPHSQA 840
SSVRATRSQQ HTPVLSSSQP LRKKPRMGF 869 
Gene Ontology
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006363; P:termination of RNA polymerase I transcription; TAS:Reactome.
 GO:0006362; P:transcription elongation from RNA polymerase I promoter; TAS:Reactome.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0006361; P:transcription initiation from RNA polymerase I promoter; TAS:Reactome. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS