CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020121
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Haloacid dehalogenase-like hydrolase domain-containing protein 3 
Protein Synonyms/Alias
  
Gene Name
 HDHD3 
Gene Synonyms/Alias
 C9orf158 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
15RLLTWDVKDTLLRLRacetylation[1, 2, 3]
15RLLTWDVKDTLLRLRubiquitination[4]
32LGEAYATKARAHGLEubiquitination[5]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
 MOD_RES 15 15 N6-acetyllysine.  
Keyword
 3D-structure; Acetylation; Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 251 AA 
Protein Sequence
MAHRLQIRLL TWDVKDTLLR LRHPLGEAYA TKARAHGLEV EPSALEQGFR QAYRAQSHSF 60
PNYGLSHGLT SRQWWLDVVL QTFHLAGVQD AQAVAPIAEQ LYKDFSHPCT WQVLDGAEDT 120
LRECRTRGLR LAVISNFDRR LEGILGGLGL REHFDFVLTS EAAGWPKPDP RIFQEALRLA 180
HMEPVVAAHV GDNYLCDYQG PRAVGMHSFL VVGPQALDPV VRDSVPKEHI LPSLAHLLPA 240
LDCLEGSTPG L 251 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0008967; F:phosphoglycolate phosphatase activity; IEA:InterPro. 
Interpro
 IPR023214; HAD-like_dom.
 IPR011949; HAD-SF_hydro_IA_REG-2-like.
 IPR006439; HAD-SF_hydro_IA_v1.
 IPR005833; Haloacid_DH/epoxide_hydro. 
Pfam
 PF13419; HAD_2 
SMART
  
PROSITE
  
PRINTS
 PR00413; HADHALOGNASE.