CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041550
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Sptbn1 
Protein Synonyms/Alias
  
Gene Name
 Sptbn1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
90RDGRMLIKLLEVLSGacetylation[1]
102LSGERLPKPTKGRMRacetylation[1]
102LSGERLPKPTKGRMRubiquitination[2]
124DKALQFLKEQRVHLEubiquitination[2]
170SVETEDNKEKKSAKDubiquitination[2]
224PDLIDFDKLKKSNAHacetylation[1]
497AESYHDIKRITARKDacetylation[1]
558LLSQDYGKHLLGVEDacetylation[1]
668LSSDDYGKDLTSVMRacetylation[1]
784YSTQSLVKKHKDVAEacetylation[1]
787QSLVKKHKDVAEEISacetylation[1]
832AGIEERYKEVAELTRacetylation[1]
924HSGHPSEKEIRAQQDacetylation[1]
924HSGHPSEKEIRAQQDubiquitination[2]
932EIRAQQDKLNTRWSQacetylation[1]
1017AKLSDLQKEAEKLESacetylation[1]
1017AKLSDLQKEAEKLESubiquitination[2]
1021DLQKEAEKLESEHPDacetylation[1]
1048SDVWEEMKTTLKNREacetylation[1]
1063ASLGEASKLQQFLRDacetylation[1]
1108LTQHENIKNEIDNYEacetylation[1]
1210GAEAAIKKQEDFMTTacetylation[1]
1249NSDRIQEKVDSIDDRacetylation[1]
1312EARNLHSKWLKHQAFacetylation[1]
1360EKLTGLHKMWEVLESacetylation[1]
1479KHNLLASKEIHQFNRacetylation[1]
1647ETVHQLSKTSRALVAacetylation[1]
1669RISMRQSKVDKLYAGacetylation[1]
1687LAEERRGKLDERHRLacetylation[1]
1809HKFYHDAKEIFGRIQacetylation[1]
1872QAAYAGDKADDIQKRacetylation[1]
1907RLVDTGDKFRFFSMVacetylation[1]
1983HYASEEIKEKLLQLTacetylation[1]
1985ASEEIKEKLLQLTEKacetylation[1]
2170PTSDRKAKSALPAQSubiquitination[2]
2234MGFYKDAKSAASGVPubiquitination[2]
2269KKKKHVFKLRLSDGNacetylation[1]
2337TSESSPGKREKDKEKacetylation[1]
2355KRFSLFGKKK*****acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2357 AA 
Protein Sequence
MTTTVATDYD NIEIQQQYSD VNNRWDVDDW DNENSSARLF ERSRIKALAD EREAVQKKTF 60
TKWVNSHLAR VSCRITDLYT DLRDGRMLIK LLEVLSGERL PKPTKGRMRI HCLENVDKAL 120
QFLKEQRVHL ENMGSHDIVD GNHRLTLGLI WTIILRFQIQ DISVETEDNK EKKSAKDALL 180
LWCQMKTAGY PNVNIHNFTT SWRDGMAFNA LIHKHRPDLI DFDKLKKSNA HYNLQNAFNL 240
AEQHLGLTKL LDPEDISVDH PDEKSIITYV VTYYHYFSKM KALAVEGKRI GKVLDNAIET 300
EKMIEKYESL ASDLLEWIEQ TIIILNNRKF ANSLVGVQQQ LQAFNTYRTV EKPPKFTEKG 360
NLEVLLFTIQ SKMRANNQKV YMPREGKLIS DINKAWERLE KAEHERELAL RNELIRQEKL 420
EQLARRFDRK AAMRETWLSE NQRLVSQDNF GFDLPAVEAA TKKHEAIETD IAAYEERVQA 480
VVAVARELEA ESYHDIKRIT ARKDNVIRLW EYLLELLRAR RQRLEMNLGL QKIFQEMLYI 540
MDWMDEMKVL LLSQDYGKHL LGVEDLLQKH ALVEADIAIQ AERVRGVNAS AQKFATDGEG 600
YKPCDPQVIR DRVAHMEFCY QELCQLAAER RARLEESRRL WKFFWEMAEE EGWIREKEKI 660
LSSDDYGKDL TSVMRLLSKH RAFEDEMSGR SGHFEQAIKE GEDMIAEEHF GSEKIRERIS 720
YIREQWANLE QLSAIRKKRL EEASLLHQFQ ADADDIDAWM LDILKIVSSN DVGHDEYSTQ 780
SLVKKHKDVA EEISNYRPTI DTLHEQAGAL PQAHAESPDV KGRLAGIEER YKEVAELTRL 840
RKQALQDTLA LYKMFSEADA CELWIDEKEQ WLNNMQIPEK LEDLEVIQHR FESLEPEMNN 900
QASRVAVVNQ IARQLMHSGH PSEKEIRAQQ DKLNTRWSQF RELVDRKKDA LLSALSIQNY 960
HLECNETKSW IREKTKVIES TQDLGNDLAG VMALQRKLTG MERDLVAIEA KLSDLQKEAE 1020
KLESEHPDQA QAILSRLAEI SDVWEEMKTT LKNREASLGE ASKLQQFLRD LDDFQSWLSR 1080
TQTAIASEDM PNTLTEAEKL LTQHENIKNE IDNYEEDYQK MRDMGEMVTQ GQTDAQYMFL 1140
RQRLQALDTG WNELHKMWEN RQNLLSQSHA YQQFLRDTKQ AEAFLNNQEY VLAHTEMPTT 1200
LEGAEAAIKK QEDFMTTMDA NEEKINAVVE TGRRLVSDGN INSDRIQEKV DSIDDRHRKN 1260
REAASELLMR LKDNRDLQKF LQDCQELSLW INEKMLTAQD MSYDEARNLH SKWLKHQAFM 1320
AELASNKEWL DKIEKEGMQL ISEKPETEAV VKEKLTGLHK MWEVLESTTQ TKAQRLFDAN 1380
KAELFTQSCA DLDKWLHGLE SQIQSDDYGK DLTTSAQNKV LDGASVFLLM YSCPPRCWRI 1440
RWKRGRAQMR DSKRLTVQTK FMELLEPLNE RKHNLLASKE IHQFNRDVED EILWVGERMP 1500
LATSTDHGHN LQTVQLLIKK NQTLQKEIQG HQPRIDDIFE RSQNIITDSS SLNAEAIRQR 1560
LADLKQLWGL LIEETEKRHR RLEEAHKAQQ YYFDAAEAEA WMSEQELYMM SEEKAKDEQS 1620
AVSMLKKHQI LEQAVEDYAE TVHQLSKTSR ALVADSHPES ERISMRQSKV DKLYAGLKDL 1680
AEERRGKLDE RHRLFQLNRE VDDLEQWIAE REVVAGSHEL GQDYEHVTML QERFREFARD 1740
TGNIGQERVD TVNHMADDLI NSGHSDAATI AEWKDGLNEA WADLLELIDT RTQILAASYE 1800
LHKFYHDAKE IFGRIQDKHK KLPEELGRDQ NTVETLQRMH TTFEHDIQAL GTQVRQLQED 1860
AARLQAAYAG DKADDIQKRE NEVLEAWKSL LDACEGRRVR LVDTGDKFRF FSMVRDLMLW 1920
MEDVIRQIEA QEKPRDVSSV ELLMNNHQGI KAEIDARNDS FTACIELGKA LLARKHYASE 1980
EIKEKLLQLT EKRKEMIDKW EDRWEWLRLI LEVHQFSRDA SVAEAWLLGQ EPYLSSREIG 2040
QSVDEVEKLI KRHEAFEKSA ATWDERFSAL ERLTTLELLE VRRQQEEEER KRRPPSPEPS 2100
AKVSEEAESQ QWDTSKGDQV SQNGLPAEQG SPRMAGTMET SEMVNGAAEQ RTSSKESSPV 2160
PSPTSDRKAK SALPAQSAAT LPARTLETPA AQMEGFLNRK HEWEAHNKKA SSRSWHNVYC 2220
VINNQEMGFY KDAKSAASGV PYHSEVPVSL KEAICEVALD YKKKKHVFKL RLSDGNEYLF 2280
QAKDDDEMNT WIQAITSAIS SDKHDTSAST QSTPASSRAQ TLPTSVVTIT SESSPGKREK 2340
DKEKDKEKRF SLFGKKK 2357 
Gene Ontology
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0008091; C:spectrin; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR001605; PH_dom-spectrin-type.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR018159; Spectrin/alpha-actinin.
 IPR016343; Spectrin_bsu.
 IPR002017; Spectrin_repeat. 
Pfam
 PF00307; CH
 PF00169; PH
 PF00435; Spectrin 
SMART
 SM00033; CH
 SM00233; PH
 SM00150; SPEC 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS50003; PH_DOMAIN 
PRINTS
 PR00683; SPECTRINPH.