Tag | Content |
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CPLM ID | CPLM-013949 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein SZT2 |
Protein Synonyms/Alias | Seizure threshold 2 protein homolog |
Gene Name | SZT2 |
Gene Synonyms/Alias | C1orf84; KIAA0467 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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755 | KLLIRYEKLPLDYRA | ubiquitination | [1] | 1163 | GPPQEETKPKFGDWS | ubiquitination | [1] |
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Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Involved in oxidative stress. May be involved in superoxide dismutase activity and in neuroprotective effect of peroxisomes, but has no direct dismutase activity when tested in yeast. May enhance epileptogenesis and confer low seizure threshold (By similarity). |
Sequence Annotation | |
Keyword | Alternative splicing; Complete proteome; Peroxisome; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 3432 AA |
Protein Sequence | MASERPEPEV EEAGQVFLLM KKDYRISRNV RLAWFLSHLH QTVQATPQEM LLQSEQELEV 60 LSVLPPGWQP DEPVVPRPFL LVPSTRVTFL AWQYRFVIEL DLSPSTGIVD DSTGEILFDE 120 VFHALSRCLG GLLRPFRVPG SCIDFQPEIY VTIQAYSSII GLQSHQVLVQ GCLLDPSQRE 180 VFLQQIYEQL CLFEDKVATM LQQQYDPQSQ AEDQSPDSGD LLGRKVGVSM VTADLGLVSM 240 IRQGILALQL LPSNSSAGII VITDGVTSVP DVAVCETLLN QLRSGTVACS FVQVGGVYSY 300 DCSFGHVPNV ELMKFIAMAT FGSYLSTCPE PEPGNLGLTV YHRAFLLYSF LRSGEALNPE 360 YYCGSQHRLF NEHLVSASSN PALALRRKKH TEKEVPADLV STVSVRLREG YSVREVTLAK 420 GGSQLEVKLV LLWKHNMRIE YVAMAPWPLE PEGPRVTRVE VTMEGGYDIL HDVSCALRQP 480 IRSLYRTHVI RRFWNTLQSI NQTDQMLAHL QSFSSVPEHF TLPDSTKSGV PLFYIPPGST 540 TPVLSLQPSG SDSSHAQFAA YWKPVLSMDA NSWQRWLHMH RLVLILEHDT PIPKHLHTPG 600 SNGRYSTIQC RISHSSLTSL LRDWSSFVLV EGYSYVKLLS SAPDQPPNSF YMVRIISKAP 660 CMVLRLGFPI GTPAPARHKI VSGLREEILR LRFPHRVQSK EPTPKVKRKG LGGAGGGSSP 720 SKSPPVLGPQ QALSDRPCLV VLHKPLDKLL IRYEKLPLDY RAPFLLTLEP PGPLPLVSGR 780 SASSSLASLS RYLYHQRWLW SVPSGLAPAL PLSAIAQLLS ILTEVRLSEG FHFACSGEGI 840 INMVLELPIQ NEPPGQAAAE EKHTCVVQYI LFPPHSTSTK DSFSTDDDND VEVEALEGDS 900 ELNLVTEVWV EPQYGRVGPG PGIWKHLQDL TYSEIPQALH PRDAACIGSM LSFEYLIQLC 960 QSKEWGPLPP EPRVSDGLDQ GGDTCVHEIP FHFDLMGLLP QCQQLQMFFL LLAREPEGVP 1020 FAEGSCPAND MVLCLLHSCL GQELSDREIP LTPVDQAAFL SEVLRRTCHV PGAEGPLLGV 1080 HGIPKEQAVG STQATGDSAF TSLSVGLPET LKPLISAQPP QWRCYARLVN PQHVFLTFLP 1140 ATFSDVQRLA ACGLEGPPQE ETKPKFGDWS GAPSLKDLGG TGIKATKSHV PVLSVTLASD 1200 NAQNQGELSP PFRRDLQAYA GRQASQTESA DGPRTRCPVY IYSCSLEALR EQMVGMQPPQ 1260 APRDLIFRTQ FLDHPSPSSA WMEPRYKEAA NHCALLQEHA QRCYVRGLFR SLQQAQSVTS 1320 QDLLTAVDAC EELLQEIDIT PFLLALCGHT WGLPHAPPSP GPLSPGPFSS SMEEGAEPRE 1380 RAILASESSI ETEDLSEPEF QSTRVPGIPD PGPEISLTDV CQLRGEAHGA LHSVIQEKFL 1440 EISRLHFRTV PSNPHYFFYC PPSSRREDEG PRDTVDRKIS DLEFSEAELM GEEGDTSACC 1500 VVTESDPELE VEYRESRESD LGPAGLDSAS LSDVDTVNPD EDSFSILGGD SPTGPESFLH 1560 DLPPLFLHLT CSVRLRGQHS SVPVCSLPTC LGQVLSSLEG PPVGGRVPLR DLSVTLDVFM 1620 LTLPLEVELP TASDPQHHRS TSESSASFPR SPGQPSSLRS DDGLGPPLPP PEEERHPGLS 1680 NLATPHRLAI ETTMNEIRWL LEDEMVGALR RGGIPQSPAL HRAAAHIHSS PGRSTCLRQT 1740 LPLSFVFGPE RSLTQFKEEF RRLHLPGHVL LEDPDSGFFF VAAGQQPGGS HGEPSSAAWA 1800 WHSHEDRAEG IEGETLTASP QAPGSPEDSE GVPLISLPRV PQGGSQPGPS RGLSLMSSQG 1860 SVDSDHLGYD GGSSGSDSEG PNDTLGEKAP FTLRTPPGPA PPQPSLSGLP GPCLPDFWLI 1920 VRVLQDRVEV YAHARSLIRE DGGPGTECRH LQQLLVRRVG EICREVNQRL LLQDLHDSHV 1980 CNSLLVAESE EDLWRSETPF HSRQRAPLPS DDYAADESCA PRGYLAATMQ FVPGHFSCDV 2040 VWGTVIRVHS RLKMGPSMGV SRAIQALRSV LNAFSVVNRK NMFVYQERAT KAVYYLRLLE 2100 TSCSDRPWKG DALPPSLALS RSQEPIYSEE ASGPRSPLDM VSSRSSDAAR PVGQVDRHIQ 2160 LLVHGVGQAG PEITDELVRV LCRRLDEATL DVITVMLVRN CKLTPADVEF IQPPGSLPSE 2220 VLHLALPTSC RPWLPALAWY LRQNLLIFLH SPKYTDSNSR NHFQHPLPPQ GGLPDLDIYL 2280 YNKPGGQGTG GKGVACITLA FVDEGGAPLS LALWPPSSPG PPDPLREEEF EQLTQVIRCP 2340 VVVDSSSAQN GAPRLRLDVW EKGNISIVQL EEKLRGAARQ ALADAIIELQ LLPASLCTED 2400 TPTGSLRNGS LETKSSAGRA STFPPAPVPG EPVTPPSKAG RRSFWDMLSK TECGDLGSPK 2460 TTDDIVLDRP EDTRGRRRHK TESVRTPGGA ERAPGSDSGA QRQKRRTTQL EEGEVGTLHP 2520 VFARVAQRWM EFMVQIGCAS VSRSSAHMVS RFLLPSILSE FTALVTSMAG DTSVRIFEQH 2580 LGSEPEIFGP CSPGQLGPSP RPAAERHLLL LGRNFLQWRR PTQQAAKAMQ RFEPGGDGSS 2640 GRNAPRQRLL LLEVVDKKLQ LLTYNWAPDL GAALGRALVR LVQWQNARAH LIFCLLSQKL 2700 GLFHHYGQLD FPVRDEKEPN PFLLPTMEVE TLIRSASPPL SREQGRLSGS SRGGGPLPLD 2760 TFPFDEALRD ITAARPSSVL GPVPRPPDPV TYHGQQFLEI KMAERRELER QMKMENLFVT 2820 WQQRSTPATM PISAGELETL KQSSRLVHYC ATAMLFDPAA WLHGPPETSG PPDGQRRHRP 2880 ESGSGSREAP TSCESLDVSP PGAREEPWLK ELSLAFLQQY VQYLQSIGFV LVPLRPPSPA 2940 RSTSRPRAMA ILGTEGRGSF SCPKTKTDGS PKSTSSPVTT YHLQRALPGG IILMELAFQG 3000 CYFCVKQFAL ECSRIPMGQA VNSQLSMLFT EECDKVRDLM HVHSFSYDFH LRLVHQHVLG 3060 AHLVLRHGYH LTTFLRHFLA HHPDGPHFGR NHIYQGTLEL PTPLIAAHQL YNYVADHASS 3120 YHMKPLRMAR PGGPEHNEYA LVSAWHSSGS YLDSEGLRHQ DDFDVSLLVC HCAAPFEEQG 3180 EAERHVLRLQ FFVVLTSQRE LFPRLTADMR RFRKPPRLPP EPEAPGSSAG SPGEASGLIL 3240 APGPAPLFPP LAAEVGMARA RLAQLVRLAG GHCRRDTLWK RLFLLEPPGP DRLRLGGRLA 3300 LAELEELLEA VHAKSIGDID PQLDCFLSMT VSWYQSLIKV LLSRFPQSCR HFQSPDLGTQ 3360 YLVVLNQKFT DCFVLVFLDS HLGKTSLTVV FREPFPVQPQ DSESPPAQLV STYHHLESVI 3420 NTACFTLWTR LL 3432 |
Gene Ontology | GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell. GO:0007417; P:central nervous system development; IEA:Compara. GO:0043473; P:pigmentation; IEA:Compara. GO:0009791; P:post-embryonic development; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |