UniProt Accession

 MED6_MOUSE; Q921D4; Q3TAK5; Q8BTP9 

Genbank Protein ID

 AK089101; AK171784; BC013096 

Genbank Nucleotide ID

 BAC40749.1; BAE42663.1; AAH13096.1 

Protein Name

 Mediator of RNA polymerase II transcription subunit 6 

Protein Synonyms/Alias

 Mediator complex subunit 6 

Gene Name

 Med6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
236	IQQTVSTKGPPEKRM	acetylation	[1, 2, 3]
241	STKGPPEKRMRLQ**	acetylation	[1, 2, 3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 

Sequence Annotation

 MOD_RES 236 236 N6-acetyllysine (By similarity).
 MOD_RES 241 241 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Activator; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 246 AA 

Protein Sequence

Gene Ontology

 GO:0016592; C:mediator complex; IDA:MGI.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0001104; F:RNA polymerase II transcription cofactor activity; IEA:InterPro.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0019827; P:stem cell maintenance; IMP:MGI. 

Interpro

 IPR007018; Mediator_Med6.
 IPR016820; Mediator_Med6_met/pln. 

Pfam

 PF04934; Med6 

SMART

  

PROSITE

  

PRINTS