UniProt Accession

 BDH_RAT; P29147; Q5U2Q2 

Genbank Protein ID

 M89902; BC085916 

Genbank Nucleotide ID

 AAB59684.1; AAH85916.1 

Protein Name

 D-beta-hydroxybutyrate dehydrogenase, mitochondrial 

Protein Synonyms/Alias

 BDH; 3-hydroxybutyrate dehydrogenase 

Gene Name

 Bdh1 

Gene Synonyms/Alias

 Bdh 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
103	VRELDSLKSDRLRTI	acetylation	[1]
132	ETVRSGLKDPEKGMW	acetylation	[1]
275	VRKDYGKKYFDEKIA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

  

Sequence Annotation

 NP_BIND 59 83 NAD (By similarity).
 ACT_SITE 208 208 Proton acceptor (By similarity).
 BINDING 195 195 Substrate (By similarity).
 MOD_RES 132 132 N6-acetyllysine (By similarity).
 MOD_RES 275 275 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Allosteric enzyme; Complete proteome; Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 343 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IDA:RGD.
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0003858; F:3-hydroxybutyrate dehydrogenase activity; IDA:RGD.
 GO:0005543; F:phospholipid binding; IDA:RGD.
 GO:0060612; P:adipose tissue development; IEP:RGD.
 GO:0007420; P:brain development; IEP:RGD.
 GO:0001889; P:liver development; IEP:RGD.
 GO:0046686; P:response to cadmium ion; IEP:RGD.
 GO:0051412; P:response to corticosterone stimulus; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0060416; P:response to growth hormone stimulus; IEP:RGD.
 GO:0032868; P:response to insulin stimulus; IEP:RGD.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0042594; P:response to starvation; IEP:RGD.
 GO:0009636; P:response to toxic substance; IEP:RGD. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.